Chemical profile, traditional uses, and biological activities of Piper chaba Hunter: A review (original) (raw)
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Preliminary pharmacological studies on Piper chaba stem bark
Journal of Ethnopharmacology, 2005
Piper chaba Hunter (Piperaceae) is a common pepper in the southern part of Bangladesh. Various parts of this plant have been extensively used in different traditional formulations including ayurveda. In order to rationalize the ethnomedical uses of this plant in a number of ailments, the methanol extract of the stem bark was subjected to preliminary evaluation for analgesic, anti-inflammatory, diuretic, anti-diarrhoeal, effect on gastrointestinal motility and CNS depressant activity in mice and rat at 125, 250 and 500 mg/kg body weight doses. The extract at given doses significantly and dose dependently reduced the frequency of acetic acid induced writhing in mice, prolonged the tail flicking latency in mice, reduced Carrageenan-induced paw edema volume in rat, delayed the onset as well as reduced the frequency of castor oil induced diarrhoeal episodes in mice, decreased gastrointestinal motility as assessed by the charcoal motility test in mice and prolonged pentobarbitone induced sleeping time in mice. However at the same doses, the extract exhibited moderate diuretic activity only at the highest dose.
Antimicrobial and Cytotoxic Activities of Root Extracts of Piper Chaba
2009
Antibacterial and antifungal properties of petroleum ether, chloroform, ethyl acetate and methanol extracts of Piper chaba (Choi) roots were studied by disc diffusion method and these activities were compared with primary standard drugs Kanamycin and Nystatin, respectively. The extracts were found to exhibit promising antibacterial and antifungal properties against Gram-positive, Gram-negative bacteria and fungi. The extracts were also studied for their cytotoxic activities by brine shrimp lethality bioassay, where gallic acid was used as primary standard. It was observed that the petroleum ether extract was potent cytotoxic with the LC 50 value of 0.95 µg/ml against Artemia salina (L). The essential oils of the petroleum ether extract of Piper chaba roots were analysed by GC/MS. It was observed that most of the compounds were sesquiterpenes, some were long chain fatty acids and some were monoterpenes and alkaloids. Seventeen compounds were identified from the GC/MS analysis.
Piper species are aromatic plants used as spices in the kitchen, but their secondary metabolites have also shown biological effects on human health. These plants are rich in essential oils, which can be found in their fruits, seeds, leaves, branches, roots and stems. Some Piper species have simple chemical profiles, while others, such as Piper nigrum, Piper betle, and Piper auritum, contain very diverse suites of secondary metabolites. In traditional medicine, Piper species have been used worldwide to treat several diseases such as urological problems, skin, liver and stomach ailments, for wound healing, and as antipyretic and anti-inflammatory agents. In addition, Piper species could be used as natural antioxidants and antimicrobial agents in food preservation. The phytochemicals and essential oils of Piper species have shown strong antioxidant activity, in comparison with synthetic antioxidants, and demonstrated antibacterial and antifungal activities against human pathogens. Moreover, Piper species possess therapeutic and preventive potential
Phytochemistry and pharmacology of three Piper species: An update.
In this review, the current knowledge on the phytochemistry and pharmacology of Piper betle (betel), Piper sarmentosum (wild pepper) and Piper caninum (wild betel) is updated with some description of their botany and uses. Leaves of P. betle contain polyphenols, alkaloids and essential oils, and display broad-spectrum antibacterial activity, substantial quorum sensing inhibition and tyrosinase enhancement activity. They also possess anti-malarial, anti-diabetic, anti-inflammatory, antinociceptive, hypoglycaemic, neuroprotective and hepatoprotective properties. Leaves of P. sarmentosum contain phenylpropanoids, phenylpropanoyl amides, dihydroflavones and essential oils. Wild pepper displays a wide array of pharmacological properties including antioxidant, antibacterial, antifungal, anti-amoebic, anti-dengue, anti-tuberculosis, cytotoxic, anti-plasmodial, neuromuscular-blocking, antinociceptive, anti-inflammatory, hypoglycaemic, anti-atherosclerosis and anti-osteoporosis activities. Leaves of P. caninum contain phenolic compounds, alkaloids and essential oils. Pharmacological properties of wild betel include antioxidant, antibacterial, antifungal, DNA-damaging, DNA strand-scission and anticancer activities. All three Piper species reviewed possess pharmacological properties, which confer their traditional and contemporary uses as food and herbal medicine.
Antimicrobial, antileishmanial and cytotoxic compounds from Piper chaba
Natural Product Research, 2012
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Journal of Herbs, Spices & Medicinal Plants, 2011
Fruits of Piper longum (Indian tipali) and Piper chaba (Bangla tipali) are widely used in traditional Indian systems of medicine, and the latter is considered as a substitute for the former. Phytochemical evaluations of these two species were carried out with reference to the volatile chemical profiles of the leaves and fruits, and piperine content of the fruits and their antioxidant potential were compared to determine the propriety of using P. chaba as a substitute for P. longum. The leaf oil of P. longum was rich with the phenyl propanoids apiole (50.0%) and myristicin (26.9%), whereas sesquiterpene hydrocarbons β-caryophyllene (28.6%), α-humulene (22.8%), and germacrene D (14.6%) were the major constituents in P. chaba leaf oil. In the fruit oil of P. longum, aliphatic compounds predominated with n-pentadecane (15.8%), whereas P. chaba fruit oil mainly had sesquiterpene hydrocarbons such as germacrene D (21.5%), β-caryophyllene (18.5%), and α-humulene (11.4%). In P. longum fruits, piperine content was lower (0.03%) compared to P. chaba fruits (1.32%). In P. chaba, the piperamides were mainly piperine, whereas other piperamides were predominant in P. longum. Antioxidant activity was higher for P. longum fruits as compared to P. chaba fruits.
Phytochemistry of the genus Piper
Phytochemistry, 1997
The secondary metabolites isolated from Piper species for the period 1907 to June 1996 have been reviewed. Nearly six hundred chemical constituents belonging to different classes of bioactive compounds are listed together with their source(s) and references. 0 1997 Elsevier Science Ltd Aristolactam A II (3) Auranamide (4) P. aduncum P. guayranum P. attenuatum P. boehimerifolium P. hamiltonii P. longum P. auranfiacum [231 [29, 301 [311 1311 1311 [31, 321 1331 Compound Phytochemistry of the genus Piper Cyclopiperstachine (23) P. aurantiacum P. aurantiacum P. brachystachyum P. brachystachyum P. nigrum P. brachystachyum P. brachystachyum P. brachystachyum P. acutisleginum P. argyrophylum P. attenuatum P. auritum P. betle P. boehimerifolium P. hamiltonii P. longum P. manuausense P. methysticum P. pedicellosum P. sanctum P. wightii P. aborescens P. argyrophylum P. attenuatum P. auritum P. boehimerifolium P. hamiltonii P. longum P. sanctum P. wightii P. argyrophylum P. attenuatum P. boehimerzyolium P. chiadoense P. longum P. wightii P. hancei P. argyrophylum P. argyrophylum P. methysticum P. schmidtii P. wightii P. argyrophylum P. peepuloides P. peepuloides P. trichostachyon [34, 351 P. trichostachyon P. trichostachyon P. chaba P. longum P. nigrum P. guineense P. novae hollandiae P. amalago P. guineense P. longum P. tuberculatum P. bartlingianum P. rugosum P. guineense P. guineense P. nigrum P. amalago P. amalago P. aborescens P. amalago P. arboricola P. nigrum P. retrofractum P. retrofractum P. amalago P. amalago P. amalago P. amalago P. verrucosum P. argyrophylum P. argyrophylum P. nigrum P. officinarum P. argyrophylum P. argyrophylum P. nigrum P. futokadsura P. hancei P. attenuatum P. brachystachyum P. guineense P. hancei P. longum P. nigrum P. officinarum P. retrofractum P. sylvaticum P. amalgo P. amalago P. amalago P. steerni P. nigrum P. attenuatum WI WI WI 1951 [761 r311 P. boehimerifolium P. longum P. ribesioides P. attenuatum P. chaba P. guineense P. hancei P. longum P. nepalense P. nigrum P. novae hollandiae P. pedicellosum P. peepuloides P. ribesioides P. sarmentosum P. sylvaticum P. wallichii P. guineense P. peepuloides P. guineense P. longum P. macropodum P. nigrum P. longum P. nigrum P. ofjeinarum P. retrofractum P. guineense P. austrosinense 1,2,3-Trimethoxy-4,5-dioxo-6a,7-dehydroaporphine (141) P. aborescens 3',4',5'-Trimethoxycinnamoylisobutylamine (142) P. amalago Plant(s) P. argyrophylum P. boehimertfolium P. pderulum P. nigrum P. callosum P. aborescens P. callosum P. Iongum P. retrofractum P. sylvaticum P. tuberculatum P. aborescens P. rugosum P. tuberculatum P. guineense P. brachystachyum P. longum P. nigrum P. retrofractum P. ridleyi P. retrofractum P. retrofractum P. ridleyi P. nigrum P. sarmentosum P. nigrum P. sarmentosum P. sylvaticum P. aurantiacum P. brachystachyum P. ehaba P. guineense P. longum P. sylvaticum P. clusii [I871 P. schmidtii P. wightii P. clusii P. cubeba P. clusii P. cubeba P. cuneifolium P. Iacunosum P. nigrum P. ribesioides P. trichostachyon P. ch4sii P. cubeba P. clusii P. cubeba P. cubeba P. longum P. peepuloides P. sylvalicum P. aborescens P. cubeba P. clusii P. cubeba P. guineense P. trichostachyon P. trichostachyon P. nigrum P. guineense P. nigrum P. mikanianum P. cubeba P. attenualum P. auritum P. nigrum P. guineense P. auritum P. guineense P. auritum P. argyrophylum P. auritum P. marginatum P. guineense P. nigrum P. argyrophylum P. auritum P. guineense P. marginatum P. nigrum P. guineense P. cubeba P. guineense P. marginatum P. nigrum P. guineense P. nigrum P. auritum P. betle P. futokadsura P. guineense P. hispidum P. nigrum P. aduncum P. auritum P. guineense P. capense P. argyrophylum P. auritum P. guineense P. marginatum P. nigrum P. auritum P. guineense P. nigrum P. nigrum P. nigrum P. nigrum P. aduncum P. auritum P. guineense P. auritum P. belle P. cubeba P. marginatum P. nigrum P. auritum P. cubeba P. guineense P. marginatum P. nigrum P. guineense P. nigrum P. belle P. guineense P. nigrum P. belle P. auritum P. cubeba P. guineense P. longum P. marginalum P. nigrum P. argyrophylum P. auritum P. cubeba P. guineense P. longum P. marginatum P. nigrum P. aduncum P. auritum P. decurrens P. methysticum P. nigrum P. lenticellosum P. aduncum P. longum P. sarmentosum P. austrosinense P. nigrum P. ribesioides P. betle P. nigrum P. longum P. hookeri P. brachystachyum P. peepuloides P. sylvaticum P. auritum P. auritum P. auritum P. marginatum P. nigrum P. clarkii P. cubeba P. cubeba P. cubeba P. cubeba P. attenuatum P. hookeri P. attenuatum P. hookeri P. polysyphorum P. polvsyphorum P. polysyphorum P. demeraranum P. saltuum P. ribesioides P. longum P. aurantiacum P. betle P. marginatum P. nigrum P. ribesioides P. nigrum P. aduncum P. methysticum P. attenuatum P. aduncum P. argyrophylum P. aurantiacum P. brachystachyum P. hookeri P. longum P. sumatranum
A Review of Bioactive Compounds and Antioxidant Activity Properties of Piper Species
Molecules
Antioxidants are compounds that are able to inhibit the negative effects that come from free radicals. The phenomenon of imbalanced antioxidant production and the accumulation of free radicals in cells and tissues can cause oxidative stress. Excessive free radicals that enter the body cannot be warded off by endogenous antioxidant compounds so that the required antioxidant compounds can come from the outside, which helps in the performance of endogenous antioxidants. Antioxidants that come from outside consist of synthetic and natural antioxidants; however, synthetic antioxidants are not an option because they have toxic and carcinogenic effects. Therefore, the use of natural ingredients is an alternative method that is needed to create a new natural antioxidant compound. Piper species are being considered as possible medicinal plants for the development of new sources of antioxidants. Several studies have been carried out starting from the extract levels, fractions, and compounds o...