Periodontal Disease and Systemic Inflammation: Reducing the Values of Serum Inflammatory Markers by Control of Local Infection (original) (raw)
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Irish Journal of Medical Science (1971 -)
Although many studies have compared circulating IL-6 and CRP concentrations in periodontal patients and controls, a limited number of studies have compared systemic inflammatory markers at baseline and follow-up and also Data on whether periodontal therapy affects serum CRP levels are inconclusive. By the virtue of this study, an attempt was made to evaluate and compare the effect of non surgical periodontal therapy on serum C-Reactive Protein levels in Generalized chronic periodontitis patients. A total of thirty patients with Generalised chronic periodontitis, within the age range of 30-70 years, were selected and underwent non surgical periodontal therapy. Further, they were put on a two month follow up after post operative phase for evaluation and comparison of pre and post values. The results of our study showed that non surgical periodontal therapy significantly reduces the serum levels of C-reactive protein along with other clinical parameters in patients with generalised chronic periodontitis.
Effect of periodontal treatment on peak serum levels of inflammatory markers
Clinical Oral Investigations, 2014
Background and objective Some subjects with untreated periodontitis exhibit elevated levels of distinct inflammatory markers in serum. The aim of the study was to assess whether nonsurgical periodontal therapy changes the levels of these markers and lowers these peaks. Methods Forty periodontally diseased subjects received nonsurgical periodontal therapy (full-mouth scaling and root planing within 48 h) with either adjunctive systemic amoxicillin and metronidazole (n=19) or placebo (n=21). Serum samples, obtained at baseline (BL) and 3 months after treatment (M3), were evaluated for 15 cytokines and 9 acute-phase proteins using the Bio-Plex bead array multianalyte detection system. For each analyte, peak values were defined as greater than the mean+2 standard deviations (SD) of measurements found in 40 periodontally healthy persons. Proportions were compared using Fisher's exact test.
Open Journal of Stomatology, 2013
The aim of this study was to compare the serum levels of high-sensitivity C reactive protein (hs-CRP), interleukin-1 beta (IL-1β), interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-α) between patients with and without periodontitis. Methods: Clinical periodontal parameters were measured at six sites per tooth in seventy-five subjects with periodontitis and in thirty-five periodontally healthy subjects. The following periodontal parameters were evaluated: the Löe-Sillness gingival index (0 -3), the Sillness-Löe dental plaque index (0 -3), the probing depth (mm), the clinical attachment level (mm), the bleeding index and the tooth mobility index. The laboratory parameters that were included in this study were the levels of hs-CRP, IL-1β, IL-6 and TNF-α, which were all assessed via Enzyme-Linked ImmunoSorbent Assay (ELISA). Inter-group significance was determined with the statistical package R; specifically, we used the Student's t-test, x 2 -test and Mann-Whitney test. Results: Concentrations of hs-CRP, IL-1β, IL-6 and TNF-α were lower in the control group than in the periodontal disease group. The concentrations of each protein (control group vs. periodontal disease group) were as follows: hs-CRP (0.5 ± 0.6 vs. 2.5 ± 2.6, respectively), IL-1β (2.1 ± 2.2 vs. 7.0 ± 11.6, respectively), IL-6 (1.9 ± 1.6 vs. 3.7 ± 4.4, respectively) and TNF-α (64.6 ± 72.3 vs. 80.0 ± 73.1, respectively). The differences between the groups showed statistical significance at p < 0.05. Conclusions: Periodontal disease was associated with increased circulating concentrations of hs-CRP, IL-1β, IL-6 and TNF-α.
Anais da Academia Brasileira de Ciências, 2019
The systemic effect of chronic periodontitis (CP) has been suggested by several studies as an etiologic factor and modulator of diseases based on the changes in the inflammatory marker levels. This study aimed to investigate the relationship between the changes in clinical periodontal outcomes and serum biomarkers (CRP, Il-6, albumin and percentage of leukocytes) after non-surgical periodontal therapy in systemically healthy adults. An interventional study was conducted with a sample of 29 individuals without CP (control group) and 33 with CP (CP group). Periodontal clinical variables were recorded, and the serum levels of inflammatory markers were measured. Statistical analysis included the chi-square and Student's t-tests and Pearson's correlation analysis. After 90 days of non-surgical periodontal treatment, a reduction of periodontal parameters and Il-6 in both groups could be observed (P < 0.001). the correlation analysis revealed a directly proportional correlation between changes in the probing depth (r = 0.349, P = 0.049) and clinical attachment level (r = 0.374, P = 0.034) with CRP in the CP group. The findings suggest a reduction of Il-6 serum concentration and periodontal clinical measures 90 days after periodontal therapy in both groups.
Journal of Babol University of Medical Sciences, 2023
Background and Objective: Periodontal diseases are chronic inflammatory diseases leading to damage to soft and hard tissue. Due to the importance of periodontal health in people, this study was designed to investigate the association between changes in the inflammatory mediators with the development of periodontal disease. Methods: The case-control study was conducted on 120 individuals who referred to University of Baghdad, Dentistry School, Department of Periodontics in three groups: healthy group, periodontitis group, and gingivitis group, every group containing 40 individuals (20 men and 20 women). The demographic data of all individuals were recorded in the information form. Periodontal parameters, including bleeding on probing (BOP), plaque index (PI), clinical attachment loss (CAL), probing pocket depth (pd) and the serum levels of Interleukin-6 (Il-6), Immunoglobulin G (IgG) by ELISA technique, C-reactive protein (CRP) were evaluated using colorimetric technique. Findings: The mean range of IL-6 was 17.3940±1.509, 17.1432±2.214, 11.3846±1.119, for periodontitis, gingivitis, and healthy groups, the mean range of CRP was 5.4477±3.771, 3.5853±3.483, 2.3813±1.134 for periodontitis, gingivitis, healthy groups, and the mean range of IgG was 12.3875±2.073, 15.0109±2.380, 9.4851±1.081 for periodontitis, gingivitis, healthy groups, respectively. Biochemical and periodontal parameters showed highly significant increase in periodontitis and gingivitis groups compared to healthy group (p<0.05). Conclusion: According to the results of this study, the high levels of inflammatory mediators are associated with periodontal disease, and increase with the progression of periodontal disease, and the transition from gingivitis to periodontitis, and the study's cutoff values can be applied to estimate healthy cases or patients with periodontal disease.
Heterogeneity of systemic inflammatory responses to periodontal therapy
2009
Aims: We investigated the effect of comprehensive periodontal therapy on the levels of multiple systemic inflammatory biomarkers.Material and Methods: Thirty patients with severe periodontitis received comprehensive periodontal therapy within a 6-week period. Blood samples were obtained at: 1-week pre-therapy (T1), therapy initiation (T2), treatment completion (T3), and 4 weeks thereafter (T4). We assessed the plasma concentrations of 19 biomarkers using multiplex assays, and serum IgG antibodies to periodontal bacteria using checkerboard immunoblotting. At T2 and T4, dental plaque samples were analysed using checkerboard hybridizations.Results: At T3, PAI-1, sE-selectin, sVCAM-1, MMP-9, myeloperoxidase, and a composite summary inflammatory score (SIS) were significantly reduced. However, only sE-selectin, sICAM, and serum amyloid P sustained a reduction at T4. Responses were highly variable: analyses of SIS slopes between baseline and T4 showed that approximately 1/3 and 1/4 of the patients experienced a marked reduction and a pronounced increase in systemic inflammation, respectively, while the remainder were seemingly unchanged. Changes in inflammatory markers correlated poorly with clinical, microbiological and serological markers of periodontitis.Conclusions: Periodontal therapy resulted in an overall reduction of systemic inflammation, but the responses were inconsistent across subjects and largely not sustainable. The determinants of this substantial heterogeneity need to be explored further.
2016
During the last years, a large number of epidemiologic studies indicated that subjects with periodontitis presented a high risk for cardio-vascular diseases. Irrespective of the described mechanisms, the systemic inflammation is the main explanation for the relationship between the chronic infection and atherosclerosis. This study proposes an assessment of the periodontal non-surgical therapy effect on the serum levels of C-reactive protein (CRP) and interleukin-6 (IL-6) in patients with atherosclerosis and periodontal disease. The periodontal status of 64 patients was evaluated and the serum levels of CRP, IL-6 and the lipid profile were determined. Afterwards, nonsurgical periodontal therapy was conducted and the patients were re-assessed after 3 months. Reduced values for the periodontal parameters and serum levels of CRP and IL-6 were achieved Subjects with an improved periodontal status after 3 months also presented low levels of CRP and IL-6, after the correction of other co-f...
World journal of preventive medicine, 2013
Background: Periodontitis has been identified as potential risk factors for systemic pathologies. The aim of this study was to investigate the relationship between periodontitis and systemic inflammatory markers, as well as, if there is a relation to severity of periodontitis. Methodology: Periodontal examinations and serum markers of inflammation levels mesaurements were performed in 50 patients. The patients with moderate periodontitis had low CAL and PD < 5mm. The patients with severe periodontitis were with high CAL and PD > 5mm. The clinical parameters of periodontitis were determined among all subjects. The LEU, CRP, and FIB for the present investigation were obtained from peripheral venous blood patients from all groups. Findings: In both moderate and severe periodontitis, the results indicated that the total leukocytes count and neutrophils had a significantly higher count (p < 0.001) among the groups with periodontitis but that there was no significance in the lymphocytes counts. The results also show a significant relation between indicators of poor periodontal status and increased levels CRP and fibrinogen. Conclusion: Periodontitis is associated with an enhanced inflammatory response expressed by higher levels of inflammatory markers. The extent of increase in these marker levels in periodontitis patients depends of severity of the disease. Significance: The association of periodontitis with WBC, CRP and fibrinogen levels appears to be contributing factors for CVD and might be a possible intermediate pathway in this association.