Recent Progress of Electrospun Herbal Medicine Nanofibers (original) (raw)
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Electrospun Herbal Extract Derived Polymer Nanocomposites for Medical Applications
Materials Science. Textile and Clothing Technology, 2015
Herbal plants have been used in medicine since ancient times due to their health benefits. The research in this field continues to reveal advantages of these plants such as antibacterial activity against multidrug-resistant bacteria and possibility to integrate extracts in fibers by electrospinning. Electrospinning is a simple, yet versatile method of creating polymer-based nanofiber web, which can be used for wound dressings, tissue engineering and drug delivery systems. In production of electrospun nanofibers a solution of biocompatible polymer and a plant extract is needed. Therefore exploration of such composition ingredients is important.
Electrospun nanofibers for pharmaceutical and medical applications
Journal of Drug Delivery Science and Technology, 2011
Nanotechnology is one of the most promising and well-grown technologies of today with many potential pharmaceutical applications. Recent research applying nanotechnology in biomedicine suggests that the technology might solve problems in areas such as controlled release, various topical administrations, gut absorption and targeted systemic delivery for tissue regeneration. Nanofibers mimic the porous topography of natural extracellular matrix (ECM), are advantageous for tissue regeneration and also for sustained release of encapsulated drug or growth factor. The present review elaborates specifically on electrospun polymeric nanofibrous scaffolds for tissue regeneration and controlled release of drugs as well as growth factors for therapeutic drug delivery.
Progress in Biomaterials
The current work focuses on the formation of nanofibrous mats without the use of toxic solvents and metallic nanoparticles utilizing polyvinyl alcohol (PVA) and a blend of nigella, honey, garlic, and olive oil. Using deionized water (DI) water as a solvent, nanofibrous mats composed of PVA/nigella/honey (PNH) and PVA/garlic/honey/olive oil (PGHO) were developed. Methanol extraction was utilized to extract the therapeutic components of nigella sativa. Antibacterial and moisture management tests (MMT) were employed to examine the antibacterial and absorbance characteristics of the PNH and PGHO nanofibrous. Scanning electron microscope (SEM) and Fourier transform infrared spectroscopy (FTIR) tests were employed to analyze the morphological and chemical characteristics. PGHO showed thermal stability up to 245 °C, and PNH withstands until 225 °C. PNH and PGHO both exhibited antibacterial activity against Staphylococcus aureus (S. aureus), with inhibition zones of 36 mm and 35 mm, respectively. The synthesized materials exhibited excellent absorbance properties, thermal stability, cytotoxicity, and the production of thin nanofibers with an average diameter between 150 and 170 nm. The samples were characterized using FTIR spectra, which confirmed the presence of all components in the developed samples. To date, extensive research on electrospinning for biomedical applications has been undertaken using a variety of hazardous solvents and metallic nanoparticles. Briefly, our objective is to develop nanofibrous materials from plant extracts through a process called "green electrospinning" to observe the synergistic effect of multiple biocomponents incorporated nanofibers avoiding toxic solvents and metallic compounds for potential biomedical applications.
Electrospun plant-derived natural biomaterials for Tissue
2014
Plant-derived natural products are being used in medicine, and they are easily available for the production and use in tissue engineering based biological applications. Utilization of plant materials to treat human diseases is a common practice followed over many decades. In fact plant and its derivatives have been actively included in health management over thousands of years. The advent of phytochemical and phytopharmacological sciences has opened an arena to elucidate the structural and biological composition of several medicinal plant products. Their pharmacological effects depend on the supply of highly active water soluble compounds; however, due to their large molecular size most compounds are unable to cross the lipid membranes of the cells and therefore result in poor absorption resulting in loss of bioavailability and efficacy. Electrospinning makes it possible to combine the advantages of utilizing these plant materials in the form of nanofibrous scaffolds for delivering ...
Recent advances in formulating electrospun nanofiber membranes: Delivering active phytoconstituents
Journal of Drug Delivery Science and Technology, 2020
Extracts derived from plant origin have been used in clinical practice for the management of burn injuries, wounds and different medical ailments, dating back many centuries. In current modern practice, the application of plant-based extracts has been extended to repair and/or regenerate soft to hard tissues using nanotechnology. Lately, the evolution of polymeric scaffolds by electrospinning technique has expanded the scope of plant-based extract in exploitation to various biomedical fields. In this work, an exhaustive literature survey was conducted out by means of scientific engines and databases such as Google Scholar, PubMed, ScienceDirect and MEDLINE. The articles published between 1933 and 2018 were included in this study to investigate the applicability of plant-based extracts using nanofibers as keywords. This review recapitulates the implementation and recent advances of plant extract incorporated in nanofibers for the domains of tissue engineering, drug delivery and wound healing. Furthermore, these scaffolds provide a high degree of porosity ensuing in the large surface area accessible for cell attachment and infiltration, gaseous/waste exchange and nutrient mobilization. These scaffolds also represent as mats to assist as skin graft replacement for proper application of the affected areas at burn sites. These scaffolds provide innovative means of encapsulating the phytoconstituents and additional options to synthetic replicas used in wound management and drug delivery. However, novel strategies need to be endorsed for large-scale generation of the fibers and succeeding in clinical translation of these outcomes.
Marine Drugs, 2019
Nanofibrous structures mimicking the native extracellular matrix have attracted considerable attention for biomedical applications. The present study aims to design and produce drug-eluting core-shell fibrous scaffolds for wound healing and skin tissue engineering. Aloe vera extracts were encapsulated inside polymer fibers containing chitosan, polycaprolactone, and keratin using the co-axial electrospinning technique. Electron microscopic studies show that continuous and uniform fibers with an average diameter of 209 ± 47 nm were successfully fabricated. The fibers have a core-shell structure with a shell thickness of about 90 nm, as confirmed by transmission electron microscopy. By employing Fourier-transform infrared spectroscopy, the characteristic peaks of Aloe vera were detected, which indicate successful incorporation of this natural herb into the polymeric fibers. Tensile testing and hydrophilicity measurements indicated an ultimate strength of 5.3 MPa (elongation of 0.63%) and water contact angle of 89 •. In-vitro biological assay revealed increased cellular growth and adhesion with the presence of Aloe vera without any cytotoxic effects. The prepared core-shell fibrous mats containing medical herbs have a great potential for wound healing applications.
Bioactive Applications for Electrospun Fibers
Polymer Reviews, 2016
Electrospinning is a versatile technique providing highly tunable nanofibrous nonwovens. Many biomedical applications have been developed for nanofibres, among which the production of antimicrobial mats stands out. The production of scaffolds for tissue engineering, fibres for controlled drug release or active wound dressings are active fields of research exploiting the possibilities offered by electrospun materials. The fabrication of materials for active food packaging or membranes for environmental applications is also reviewed. We attempted to give an overview of the most recent literature related with applications in which nanofibres get in contact with living cells and develop a nano-bio interface.
Electrospun Nanofibers for Tissue Engineering with Drug Loading and Release
Pharmaceutics
Electrospinning technologies have been applied in the field of tissue engineering as materials, with nanoscale-structures and high porosity, can be easily prepared via this method to bio-mimic the natural extracellular matrix (ECM). Tissue engineering aims to fabricate functional biomaterials for the repairment and regeneration of defective tissue. In addition to the structural simulation for accelerating the repair process and achieving a high-quality regeneration, the combination of biomaterials and bioactive molecules is required for an ideal tissue-engineering scaffold. Due to the diversity in materials and method selection for electrospinning, a great flexibility in drug delivery systems can be achieved. Various drugs including antibiotic agents, vitamins, peptides, and proteins can be incorporated into electrospun scaffolds using different electrospinning techniques and drug-loading methods. This is a review of recent research on electrospun nanofibrous scaffolds for tissue-en...
Biomedical Applications of Electrospun Nanofibers: Drug and Nanoparticle Delivery
Pharmaceutics
The electrospinning process has gained popularity due to its ease of use, simplicity and diverse applications. The properties of electrospun fibers can be controlled by modifying either process variables (e.g., applied voltage, solution flow rate, and distance between charged capillary and collector) or polymeric solution properties (e.g., concentration, molecular weight, viscosity, surface tension, solvent volatility, conductivity, and surface charge density). However, many variables affecting electrospinning are interdependent. An optimized electrospinning process is one in which these parameters remain constant and continuously produce nanofibers consistent in physicochemical properties. In addition, nozzle configurations, such as single nozzle, coaxial, multi-jet electrospinning, have an impact on the fiber characteristics. The polymeric solution could be aqueous, a polymeric melt or an emulsion, which in turn leads to different types of nanofiber formation. Nanofiber properties...
Electrospinning of polymeric nanofibers for drug delivery applications
Journal of Controlled Release, 2014
Electrospinning has been recognized as a simple and versatile method for fabrication of polymer nanofibers. Various polymers that include synthetic, natural, and hybrid materials have been successfully electrospun into ultrafine fibers. The inherently high surface to volume ratio of electrospun fibers can enhance cell attachment, drug loading, and mass transfer properties. Drugs ranging from antibiotics and anticancer agents to proteins, DNA, RNA, living cells, and various growth factors have been incorporated into electrospun fibers. This article presents an overview of electrospinning techniques and their application in drug delivery.