Serum Aminotransferases Level in Patients with Type 2 Diabetes Mellitus attending a Tertiary Care Center, Kathmandu (original) (raw)
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Journal of Medical Sciences, 2021
Objectives This study is aimed to find out the relation of Diabetic control with serum Alanine aminotransferase in patients with Non Alcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus. Material and methods This cross sectional descriptive study was conducted from August to October 2019 in general medical outpatient department of Khyber Teaching Hospital Peshawar, a tertiary care hospital in Khyberpakhtunkhwa, Pakistan. Patients with non Alcohohol Fatty Liver Disease and T2DM were categorized into two groups. Group A with HbA1c from 6.5-8% and group B with HbA1c of more than 8%. Serum Alanine aminotransferase levels were correlated in these groups with the level of HbA1c. Data was collected through a specially designed proforma and was analyzed through statistical package for social sciences, SPSS version 23. Results Amongst 452 patients with T2DM, 289 were females and the rest of 163 were males, NAFLD was present in 197 patients. Amongst these 197 patients Serum Alanine amin...
International journal of multidisciplinary and current research, 2017
Background: This is a study of liver function tests in type two diabetic patients reveal that abnormal tests are not uncommon encounter in those in whom their diabetes is poorly controlled and it is regarded as a predictor for nonalcoholic fatty liver disease. Aim of this study: To study the correlation between liver transaminases (alanine aminotransferase and aspartate aminotransferase) and non-alcoholic fatty liver disease in type two diabetic patients. Patients and methods: In this cross sectional study conducted at diabetic and endocrine centre in A-Sadr medical city in Najaf, from February 2014 to March 2015 , a total of 120 type 2 diabetic patients were included (Male 39 and Female 81). Several different factors were studied like age, sex, type of treatment, body mass index and control of diabetes by measuring glycated hemoglobin. Liver transaminases (alanine aminotransferase and aspartate aminotransferase) was done to all those patients and the results are compared with these...
Abnormal Liver Parameters among Individuals with Type 2 Diabetes Mellitus Nepalese Population
Biochemistry & Pharmacology: Open Access, 2018
Background: Diabetes Mellitus (DM) is one of the major lifestyle-related metabolic disorders with emerging high incidence around the globe. The prevalence of type 2 Diabetes Mellitus is around 4.5% among Nepalese population as per the data of 2013 and the trend is just increasing yearly. Among various complications associated with DM, different patterns of liver diseases like fatty liver, cirrhosis and acute liver failure also count to be crucial ones. Early assessment of liver profile parameters provides better information for the management and cure of possible liver damages in type 2 diabetic population. The present study aimed to assess and compare liver parameters in Nepalese type 2 diabetic population. Methods: A total number of 300 patients were included in descriptive cross-sectional study conducted at Manmohan Memorial Teaching Hospital. Among them, 162 were type 2 Diabetic and 138 were non-Diabetic control population. Fasting blood sugar (FBS) and HbA1c were estimated to diagnose Diabetes Mellitus and Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT), Alkaline Phosphatase (ALP), total protein and albumin were estimated to assess liver function by using standard methods. The parameters were analyzed with SPSS version 20.0 and data with p-value less than 0.05 was considered as statistically significant. Results: We observed increased level of ALT (57%) and AST (46%) among patients with diabetes mellitus. Moreover, a significant level of elevation in AST and ALT was observed among the patients with DM compared to non-diabetic controls (p<0.001). Although not significant statistically, the level of ALP was also high among the diabetic group of patients. However, total protein, albumin and A/G ratio were significantly decreased in diabetic group of patients compared to non-diabetic controls. In addition, transaminases were also significantly associated with duration of diabetes. The levels of HbA1c were positively correlated with transaminases at significant level. Conclusion: Type 2 DM is associated with mild chronic changes in transaminases and decrease hepatic functions. Routine assessment of liver parameters in those populations may prevent further complications associated with liver due to insulin resistance.
2002
It has been proposed that liver dysfunction may contribute to the development of type 2 diabetes. The aim of the present study was to examine whether elevated hepatic enzymes (alanine aminotransferase [ALT], aspartate aminotransferase [AST], or ␥-glutamyltranspeptidase [GGT]) are associated with prospective changes in liver or whole-body insulin sensitivity and/or insulin secretion and whether these elevated enzymes predict the development of type 2 diabetes in Pima Indians. We measured ALT, AST, and GGT in 451 nondiabetic (75-g oral glucose tolerance test) Pima Indians (aged 30 ؎ 6 years, body fat 33 ؎ 8%, ALT 45 ؎ 29 units/l, AST 34 ؎ 18 units/l, and GGT 56 ؎ 40 units/l [mean ؎ SD]) who were characterized for body composition (hydrodensitometry or dual-energy X-ray absorptiometry), wholebody insulin sensitivity (M), and hepatic insulin sensitivity (hepatic glucose output [HGO] during the low-dose insulin infusion of a hyperinsulinemic clamp) and acute insulin response (AIR) (25-g intravenous glucose challenge). Sixty-three subjects developed diabetes over an average follow-up of 6.9 ؎ 4.9 years. In 224 subjects, who remained nondiabetic, follow-up measurements of M and AIR were available. At baseline, ALT, AST, and GGT were related to percent body fat (r ؍ 0.16, 0.17, and 0.11, respectively), M (r ؍ ؊0.32, ؊0.28, and ؊0.24), and HGO (r ؍ 0.27, 0.12, and 0.14; all P < 0.01). In a proportional hazard analysis with adjustment for age, sex, body fat, M, and AIR, higher ALT [relative hazard 90th vs. 10th centiles (95% CI): 1.9 (1.1-3.3), P ؍ 0.02], but not AST or GGT, predicted diabetes. Elevated ALT at baseline was associated prospectively with an increase in HGO (r ؍ 0.21, P ؍ 0.001) but not with changes in M or AIR (both P ؍ 0.1). Higher ALT concentrations were cross-sectionally associated with obesity and whole-body and hepatic insulin resistance and prospectively associated with a decline in hepatic insulin sensitivity and the development of type 2 diabetes. Our findings indicate that high ALT is a marker of risk for type 2 diabetes and suggest a potential role of the liver in the pathogenesis of type 2 diabetes.
Association of serum liver enzyme Alanine Aminotransferase (ALT) in patients with type 2 diabetes
Pakistan Journal of Medical Sciences
Objectives: To assess the association of raised serum liver enzyme (ALT) with type 2 diabetic subjects. Methods: This retrospective data was accessed at Baqai Institute of Diabetology and Endocrinology (BIDE) from January 2005 to May 2016. A total of 1966 subjects with type 2 diabetes were included in the study. Subjects were divided into two groups; in group A 1284 subjects had ALT within the normal range (ALT≤35iu/l) and in Group-B 682 subjects had elevated ALT (ALT>35iu/l). Details of demographics, anthropometric measurements and biochemical results at baseline were extracted from the health management system of BIDE. Data analysis was conducted on Statistical Package for Social Sciences (SPSS) version 20. Results: Out of 1966 type 2 diabetic subjects 1284(65.4%) were observed with normal value of ALT (≤35) and 682(34.6%) with elevated ALT (>35). Overall mean age of subjects was 54.66±10.98 years and mean BMI was 27.34±5.99 kg/m 2. Significant difference was observed between the groups in age (if ALT>35), gender (more likely to be male) and triglyceride (higher if ALT>35).Whereas no significant difference was found between the groups in HbA1c, cholesterol, HDL and LDL. Conclusion: High frequency of elevated ALT suggests the association of liver disease with type 2 diabetes. The type 2 diabetic subjects need to be routinely screened and further studies to assess the possible associations with NAFLD and insulin resistance are required to further clarify the disease process.
2021
Original Research Article Diabetes mellitus is a Chronic metabolic disorder characterized by the presence of hyperglycemia due to defective insulin secretion, defective insulin action or both. This study was conducted to find out the prevalence of the various liver disease in the Type 2 Diabetic Patients. Total 96 subjects were enrolled, 48 Type 2 Diabetic Patients and 48 Non Diabetic subjects. There were significantly increase serum Glucose, serum Alaninine Transaminase, serum Aspartate Transaminase, serum Alkaline Phosphatase and Serum Gamma Glutamyl Transpeptidase in Type 2 Diabetic subjectes while a statistically non-significant difference were observed in the serum Total Protein, serum Albumin and serum Total Bilirubin in Type-2 diabetic subjects.
Hepatic Involvement with Elevated Liver Enzymes in Nepalese Subjects with Type 2 Diabetes Mellitus
International Journal of Biochemistry Research & Review, 2017
Background: Diabetes mellitus (DM) is characterized by a broad disturbance in metabolism. Since the liver plays a vital role in the regulation of metabolism, there is evidence of liver dysfunction in DM. There is a high prevalence of non-alcoholic fatty liver disease among diabetic patients in western countries. However, there is a paucity of data showing of such association in Nepalese patients with DM. Therefore, the present study was carried out for a better understanding of alteration of liver function in patients with type 2 DM (T2DM). Methods: A total of 105 patients (age between 30-74 years, male/female ratio=0.6), newly Original Research Article
Study on Liver Dysfunction in Type 2 Diabetic Patients in Bangladesh
Euroasian journal of hepato-gastroenterology
Diabetes mellitus (DM) represents one of the major lifestyle-related pathological conditions; the incidence and prevalence of DM have reached an epidemic level around the world. Diabetes mellitus is usually associated with obesity, coronary diseases, and cerebral pathologies. However, more insights are required to evaluate a temporal relation between DM and hepatic functions. This study assesses whether and to what extent liver functions are modified in DM patients. A total of 100 patients with type 2 DM and 100 normal healthy controls were enrolled in this study following proper scrutiny of inclusion and exclusion criteria. Different parameters of liver function tests were measured in patients in the two groups. Data were analyzed to assess the extent and magnitude of abnormal liver functions in DM. The levels of bilirubin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), albumin, and prothrombin time were 0.737 ± 0.311 mg/dL, 39.00 ± 24.21 IU/L, 26.42 ± 10.40 IU/L...