NFκB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses (original) (raw)
Crystallographic comparison of the estrogen and progesterone receptor's ligand binding domains
Shawn Williams
Proceedings of the National Academy of Sciences, 1998
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Structural plasticity in the oestrogen receptor ligand-binding domain
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Ligand-Selective Interdomain Conformations of Estrogen Receptor-α
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Regulation of the structurally dynamic N-terminal domain of progesterone receptor by protein-induced folding
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ACS chemical biology, 2016
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Nature Structural & …, 2002
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Structural and functional relationships of the steroid hormone receptors’ N-terminal transactivation domain
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Predictive features of ligand-specific signaling through the estrogen receptor
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Three-Dimensional Models of Estrogen Receptor Ligand Binding Domain Complexes, Based on Related Crystal Structures and Mutational and Structure−Activity Relationship Data
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Structure-Based Approach for the Discovery of Novel Selective Estrogen Receptor Modulators
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Current Medicinal …, 2011
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The estrogen receptor: a structure-based approach to the design of new specific hormone–receptor combinations
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The dynamic structure of the estrogen receptor
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Journal of amino acids, 2011
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Molecular basis of agonism and antagonism in the oestrogen receptor
Andrzej Brzozowski
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Comparison of crystal structures of human androgen receptor ligand-binding domain complexed with various agonists reveals molecular determinants responsible for binding affinity
Jesus XD
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Identification of Ligands with Bicyclic Scaffolds Provides Insights into Mechanisms of Estrogen Receptor Subtype Selectivity
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Journal of Biological Chemistry, 2006
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Delineation of a unique protein-protein interaction site on the surface of the estrogen receptor
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Proceedings of The National Academy of Sciences, 2005
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Crystal Structure of a Mutant hERα Ligand-binding Domain Reveals Key Structural Features for the Mechanism of Partial Agonism
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Journal of Biological Chemistry, 2001
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Multiple-Targeting and Conformational Selection in the Estrogen Receptor: Computation and Experiment
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Chemical Biology & Drug Design, 2011
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Crystal Structure of the T877A Human Androgen Receptor Ligand-binding Domain Complexed to Cyproterone Acetate Provides Insight for Ligand-induced Conformational Changes and Structure-based Drug Design
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Journal of Biological Chemistry, 2007
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A Metastable Contact and Structural Disorder in the Estrogen Receptor Transactivation Domain
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Investigating the in Vitro Thermal Stability and Conformational Flexibility of Estrogen Receptors as Potential Key Factors of Their in Vivo Activity
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Structural Basis for the Deactivation of the Estrogen-related Receptor γ by Diethylstilbestrol or 4-Hydroxytamoxifen and Determinants of Selectivity
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Journal of Biological Chemistry, 2004
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Translational machinery and protein folding: Evidence of conformational variants of the estrogen receptor alpha
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Estrogen Receptor α- and β-Interacting Proteins Contain Consensus Secondary Structures: An Insilico Study
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Annals of Neurosciences, 2017
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The nature of the ligand-binding pocket of estrogen receptor alpha and beta: The search for subtype-selective ligands and implications for the prediction of estrogenic …
Rajeev Muthyala
Pure and Applied Chemistry, 2003
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