Exosome Production Is Key to Neuronal Endosomal Pathway Integrity in Neurodegenerative Diseases (original) (raw)

Dysfunction of the endosomal-lysosomal system is a prominent pathogenic factor in Alzheimer's disease (AD) and other neurodevelopmental and neurodegenerative disorders. Researchers have identified alterations in exosome production related to neuronal endosomal pathway integrity, especially in cases of Down syndrome and in individuals expressing the apolipoprotein E ε4 allele, a major risk factor for late-onset AD. This review explores the interdependence between exosomal biogenesis and the endosomal-lysosomal system, proposing that enhanced exosome secretion may mitigate pathological disruptions within the endosomal pathway, thereby suggesting therapeutic avenues for preserving exosome production in neurodegenerative diseases.