Peroxisomal Properties with Potential Regulatory Implications: Selective ATP Requirement for Fatty Acid Oxidation and Membrane Protein Phosphorylation (original) (raw)

Proceedings in Life Sciences, 1987

Abstract

Peroxisomal fatty acid oxidation in rat liver isolated hepatocytes occurs at a lower rate and with different substrate specificity, than in cell free in vitro systems. Acyl-CoA availability might explain the difference, but our finding that phenothiazines selectively inhibit peroxisomal fatty acid oxidation (Biochem. Biophys. Res. Commun. 120:505, 1984) raises the possibility of alternative explanations. Substrate access into the organelle might be a regulated step for which several mechanisms have been proposed (Ann. N.Y. Acad. Sci, vol. 386, 1982). Our recent description of channels or pores in the peroxisomal membrane (Labarca et al., this symposium) adds a novel structure relevant to transmembrane molecular exchanges.

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