Helicobacter pyloriinfection and micronutrient deficiencies (original) (raw)
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Hematology, Transfusion and Cell Therapy
This study aimed to investigate the relationship between hematological parameters, serum iron, and vitamin B 12 levels in adult hospitalized Palestinian patients infected with Helicobacter pylori. Methods: This case-control study included 150 adult (18-50 years old) patients infected with H. pylori and 150 healthy adults. A complete blood count was performed, and serum iron and vitamin B 12 levels of the patients were measured, statistically analyzed and compared with the control group. All parameters in cases were reassessed after the triple treatment of omeprazole 20 mg b.i.d., amoxicillin 1 g b.i.d., and clarithromycin 500 mg b.i.d. for 14 successive days. The triple treatment was the same for males and females. Results: The results revealed that the mean levels of hemoglobin, red cell count, white cell count and hematocrit were significantly lower and the red blood cell distribution width significantly higher in cases compared to controls, while no significant differences were found for mean corpuscular volume, mean corpuscular hemoglobin and platelet count. Serum vitamin B 12 and iron levels were significantly lower in cases compared to controls (262.5 ± 100.0 vs. 378.2 ± 160.6 pg/mL and 71.6 ± 24.8 vs. 80.1 ± 20.7 g/dL, respectively). Vitamin B 12 and serum iron increased significantly and was restored to close to normal levels after medical treatment. Conclusions: H. pylori infection appears to cause decreases in vitamin B 12 , iron levels and some hematological parameters. However, these were almost normalized after treatment with omeprazole, amoxicillin and clarithromycin. H. pylori is associated with vitamin B 12 and iron deficiency, thus, this may be a useful marker and a possible therapeutic agent of anemic patients with gastritis.
Significance of Helicobacter Pylori in Iron Deficiency
International Journal for Research in Applied Science & Engineering Technology (IJRASET), 2021
This article discusses the importance of helicobacter pylori in iron deficiency. It is well known that iron deficiency is one of the major problems in medicine today. The following article examines the complications of this disease and the effective methods used to treat it.
European Journal of Clinical Nutrition, 2010
Background/Objectives: Helicobacter pylori infection and iron and vitamin B 12 deficiencies are widespread in economically disadvantaged populations. There is emerging evidence that H. pylori infection has a negative effect on the absorption of these micronutrients. The aim of this study was to evaluate the effect of H. pylori infection on the efficacy of micronutrient (including iron and vitamin B 12 )-fortified foods supplied for 1 year in marginally nourished children. Subjects/Methods: In all, 543 Indian children, aged 6-10 years, participated in a double-blind, randomized controlled intervention trial, receiving foods fortified with either high (100% Recommended Dietary Allowances (RDA)) or low (15% RDA) amounts of iron, vitamin B 12 and other micronutrients. The presence of H. pylori infection was diagnosed by the 13 C-labeled urea breath test at 11 months after the start of the intervention. Blood hemoglobin, serum ferritin (SF), total body iron and plasma vitamin B 12 were estimated at baseline and 12 months, and differences between these time points were assessed using an independent t-test. Results: Overall, the prevalence of H. pylori infection in this group of children was 79%. Baseline hemoglobin, SF, body iron and vitamin B 12 concentrations were not associated with H. pylori infection. The response to the intervention (either high or low amounts of iron and vitamin B 12 fortification) in terms of change in iron markers and vitamin B 12 status did not differ between children with and without H. pylori infection.
2015
The association between Helicobacter pylori (HP) infection and concentration of folate or homocysteine are still unclear. The aim of the present study was to assess the effect of HP infection on folate and homocysteine concentrations in patients infected with HP and healthy participants. We also assessed dietary intakes of folate, vitamins B6 and B12 in two groups. In this case-control study, 44 participants with HP-infection and 46 healthy controls were studied. Participants were recruited from those referred to the central laboratory of Tabriz University of Medical Sciences. Blood samples were collected to determine serum folate and homocysteine levels. The presence of both IgG and IgA in serum was considered as HP positive. Dietary intakes were assessed in all participants by 24-hour dietary recalls by trained interviewers for three days. The mean concentration of serum folate was significantly lower in HP-positive patients than in controls (8.49 nmol/L vs. 10.95 nmol/L, respect...
Gut Microbes
Helicobacter pylori infection is predominantly acquired early in life. The prevalence of the infection in childhood is low in developed countries, whereas in developing countries most children are infected by 10 y of age. In poor resource settings, where malnutrition, parasitic/enteropathogen and H. pylori infection co-exist in young children, H. pylori might have potentially more diverse clinical outcomes. This paper reviews the impact of childhood H. pylori infection in developing countries that should now be the urgent focus of future research. The extra-gastric manifestations in early H. pylori infection in infants in poor resource settings might be a consequence of the infection associated initial hypochlorhydria. The potential role of H. pylori infection on iron deficiency, growth impairment, diarrheal disease, malabsorption and cognitive function is discussed in this review.
Helicobacter pylori: A Cause of Vitamin B12 Deficiency (A Hospital Based Multidisciplinary Study)
World Applied Sciences …, 2011
The present work was carried out to determine the frequency of vitamin B12 deficiency in Helicobacter pylori infected patients.This cross sectional study was conducted at Liaquat University Hospital and Dow University of Health Sciences, Pakistan. All patients above 12 years of age, of either gender with Helicobacter pylori infection and had raised MCV (>96 fl) were further evaluated for serum vitamin B12 level. The data was analyzed in statistical software (SPSS) and the P-value =0.05 was considered as statistically significant. One hundred and fifty (150) Helicobacter pylori infected patients with means age 44.3176±15.9114 (males) and 49.6308±15.1612 (females) were enrolled and evaluated. The Vitamin B12 deficiency was observed in 72(48.0%) subjects. The mean ± SD of serum vitamin B 12 level in overall subjects (male and female) was 308.717±223.447 and 257.342±31.919 (P=0.001), respectively. The mean vitamin B12 level in Helicobacter pylori infected subjects (male and female) with low serum vitamin B12 level was 136.250±21.423 and 142.625±19.969 (P=0.22) where as it was is 532.459±157.448 and 618.170±141.931 (P=0.01) in Helicobacter pylori infected subjects (male and female) with normal serum vitamin B12 level. In conclusion, Vitamin B12 deficiency is more pronounced in Helicobacter pylori infection.