Collagenous colitis (original) (raw)

Collagenous colitis: A Case Report and Review of the Literature

Journal of King Abdulaziz University-Medical Sciences, 2000

Collagenous colitis is a disorder characterized by chronic nonbloody watery diarrhea together with abdominal pain. The diagnosis is only achieved by colonic biopsy, which is required to rule out conditions with similar presentation. Since it was first described in 1976, several similar cases were reported in the literature. We are reporting our first case of Collagenous colitis together with review of the literature with emphasis on different presentations, pathogenesis and suggested treatment.

Collagenous colitis: Recent developments

2003

SUMMARY Collagenous colitis and lymphocytic colitis are two chronic inflammatory conditions, involving the large bowel. These two interesting entities, are usually referred to under the general term microscopic colitis. Collagenous colitis is characterized by watery diarrhea, abdominal bloating and mild loss of weight. The true incidence is unknown. However, it has been estimated that it is unlikely to exceed one case per 100000 population. The etiology is unknown, although the use of non-steroidal anti-inflammatory drugs and lansoprazole, as well as infection by Yersinia enterocolitica have been implicated in the pathogenesis of the disease. The role of activated eosinophils seems to be quite important. Diagnosis requires the histological detection of a thick subepithelial collagen band on large bowel mucosa biopsies. Treatment includes the administration of mesalamine, corticosteroids, budesonide, cholestyramine, as well as methotrexate, pendoxyphylline and octeotride. Surgery is ...

Development of collagenous colitis in inflammatory bowel disease: two case reports and a review of the literature

Gastroenterology Report, 2017

The occurrence of collagenous colitis (CC) in patients with pre-existing inflammatory bowel diseases (IBD) is rare, with only seven cases reported in the past. Herein, we report two IBD cases who developed CC after successful treatment of their IBD with two different tumor necrosis factor (TNF)-a inhibitors, which have been previously reported to successfully treat refractory CC. This report highlights the need to do random biopsies of the colon for CC diagnosis in IBD patients with symptoms of diarrhea after complete mucosal healing. The report also reviews plausible mechanisms as to how CC may develop, including the role of multiple medications.

Evolution of Collagenous Colitis into Severe and Extensive Ulcerative Colitis

The Canadian journal of gastroenterology, 2007

Collagenous colitis is an inflammatory mucosal disorder of the colon with distinctive histopathological features, including a thickened subepithelial collagen layer. The clinical course is usually benign, but serious complications, including death, may occur. In the present report, a 69-year-old woman with watery diarrhea and collagenous colitis developed bloody diarrhea that was refractory to treatment medications, including corticosteroids and azathioprine. Endoscopic and histopathological studies showed a focal neutrophilic inflammatory process that progressed to a diffuse and extensive form of colitis, eventually requiring total proctocolectomy. Careful histological review of the resected colon showed no evidence of persistent collagenous colitis. These findings suggest an important need for continued long-term follow-up of patients with collagenous colitis because superimposed and serious colonic complications may occur, including a severe and extensive pancolitis refractory to medications and necessitating total proctocolectomy.

Collagenous and lymphocytic colitis. evaluation of clinical and histological features, response to treatment, and long-term follow-up

The American journal of gastroenterology, 2003

Data on collagenous colitis (CC) and lymphocytic colitis (LC) have been based on retrospective studies of registries of patients from multiple hospitals. Such studies may induce a selection of patients with severe forms of the disease, and conclusions about the clinical spectrum of the disease and treatment efficacy are difficult to be drawn. The aim of this study was to compare the clinical features, response to treatment, and long-term follow-up of CC and LC in a large group of patients prospectively diagnosed in a single center. A specific program was undertaken to prospectively diagnose all patients with microscopic colitis from those referred for a full colonoscopy because of recurrent or chronic diarrhea. Detailed clinical and histological features, response to treatment, and long-term follow-up were compared in patients with confirmed CC and LC. Thirty-seven patients with CC and 44 with LC were included. Patients with CC were significantly younger and had a significantly long...

Collagenous gastritis and collagenous colitis: a report with sequential histological and ultrastructural findings

Gut, 1999

The case is reported of a young adult man with collagenous gastritis, an extremely rare disorder with only three case reports in the English literature, who subsequently presented with collagenous colitis. Sequential gastric biopsies showed a notable increase in thickness of the subepithelial collagen band. Ultrastructural study of gastric and rectal mucosa showed the characteristic subepithelial band composed of haphazardly arranged collagen fibres, prominent degranulating eosinophils, and activated pericryptal fibroblasts. (Gut 1999;44:881-885)