Oxidative stress: From basic research to clinical application (original) (raw)

1991, The American Journal of Medicine

02 -, superoxide anion One-electron reduction state, formed in many autoxidation reactions (for example, flavoproteins, redox cycling) H02., perhydroxy radical Protonated form of 02 ', more lipid soluble H202, hydrogen peroxide Two-electron reduction state, formed from 0~. (H02') by dismutation or directly from 02 HO. (OH.), hydroxyl radical Three-electron reduction state, formed by Fenton reaction, metal (iron)-catalyzed Haber-Weiss reaction; highly reactive RO., alkoxy radical Oxygen-centered organic (for example, lipid) radical RO0., peroxy radical Formally formed from organic (for example, lipid) hydroperoxide, ROOH, by hydrogen abstraction ROOH Organic hydroperoxide (for example, lipid-, thymine-OOH) lag 0 2 (also 102) Singlet molecular oxygen, first excited state~ 22 kcal/mol above ground state (triplet) ~02; red (dimol) or infrared (monomol) photoemission RO (also RO*)