Increased Neuroinflammation in Asymptomatic LRRK2 Mutation Carriers: A Pilot PET Imaging Study (P4.321) (original) (raw)

Neurology, 2016

Abstract

Objective: To investigate if subjects that carry LRRK2 mutations, a known risk factor for Parkinson’s disease (PD), exhibit increased neuroinflammation compared to age matched healthy controls. Background: LRRK2 is known to play a role in the regulation of the innate immune system and response to inflammation. Similarly, neuroinflammation is hypothesized to be a likely contributor to PD origin and its progression. Thus, we investigated if increased neuroinflammation could be a mechanism by which LRRK2 mutations increase the risk of PD. Methods: In this pilot study we imaged 4 Healthy Controls (HC) (age 44 ± 16, mean, std; range 24-63) and 3 age matched unaffected LRRK2 G2019S mutation carriers (UC)(age 51 ± 12, mean, std; range 37-61) with 11C-PBR28, a second generation TSPO binding PET ligand. All subjects were mixed affinity binders (MAB). 38 MRI guided regions of interest were placed on the PET images. The primary outcome measures were standard uptake values (SUV), previously cro...

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