Human α1-foetoglobulin during the last trimester of gestation (original) (raw)

Clinica Chimica Acta, 1972

Abstract

The best known foetoprotein is alphafetaglobulin (AFG). The highest levels are in the blood between weeks 10-12 of intrauterine life. The concentration decreases until birth and disappears within 2-3 weeks. The alphaglobulin concentrations of 134 infants were determined at birth. 47 infants were full-term (between 38-42 weeks), 68 were premature (before 38 weeks), and 19 were small-for-date. The level decreases progressively in a nonlinear pattern during the last trimester of gestation. The level decreases rapidly after birth, regardless of the maturity of the infant. The test was not a biochemical indicator of maturation because of individual variations in alphafetoglobulin concentration with both increasing gestational age and birth weight.

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