Localized morphea: a rare adverse effect of valproic acid (original) (raw)
Related papers
Onychomadesis: A rare adverse effect in early-period valproic acid therapy
Türk Pediatri Arşivi, 2017
Valproic acid is an effective, frequently used anticonvulsant drug. Typical adverse effects include weight gain, hair loss, and nausea. Hyperpigmentation, onycholysis, and onychomadesis are nail changes that can be seen after valproic acid use. Changes occur at the distal and proximal portions of the nail bed in onycholysis and onychomadesis, respectively. Onychomadesis is a very rare disease of childhood with the exception of systemic and genetic diseases. Here, we present a child aged 23 months, the youngest and the earliest isolated patient with onychomadesis, which occurred after valproic acid treatment and worried the family but resolved spontaneously. The improvement of this very rare adverse effect of antiepileptic drugs after cessation of valproic acid without treatment is emphasized.
Fatal toxic epidermal necrolysis induced by sodium valproate. Pak J Pharm Sci. 2013 May;26(3):637-9. [PubMed] PMID:23625442, 2013
A 26 years old manual labourer from Azad Jammu Kashmir presented with four days history of an extensive exfoliation of skin involving the entire body. Histology of the lesion showed epidermal necrolysis. The patient was a recently diagnosed case of epilepsy and had been started on therapy with sodium valproate three weeks ago. Following admission in our center, intensive care and wound care were instituted according to standard protocols. Despite all therapeutic measures the patient kept on deteriorating and developed multi-organ failure with pneumonia. He died on 7 th day of hospitalization.
Valproic acid (VPA) is a broad-spectrum antiseizure drug used for a variety of clinical conditions, such as epilepsy and mood disorders. Drug-induced hypersensitivity syndrome (DRESS) accompanied by hyponatremia, thrombocytopenia, hypoalbuminemia and elevated aminotransferase has never been reported as an adverse effect of VPA monotherapy during titration for epilepsy in Asian population. Hereby, we present the case of a 73-year-old Chinese male who suffered from DRESS and other complications two weeks after initiating VPA treatment for epilepsy. Understanding the risk associated with VPA-induced DRESS, and taking effective measures to avoid the severe side effects are necessary.
Valproic acid hypersensitivity and desensitization
Developmental Medicine & Child Neurology, 2015
ABBREVIATIONS AED Antiepileptic drug Rash, a hypersensitivity reaction, is a common cause of withdrawal from an effective antiepileptic drug (AED) in patients with epilepsy. We present a case of successful desensitization to valproic acid in a 12-year-old male with childhood absence epilepsy and a hypersensitivity reaction, whose epilepsy did not respond to other AEDs. Desensitization is a practical therapeutic solution for patients who develop a non-life-threatening hypersensitivity reaction to an AED for which there may be no substitute.
Reye-like syndrome associated with valproic acid therapy
The Journal of Pediatrics, 1979
ment of encephal0pathy, the apparent rarity of the condition does not warrant special precautions in the use of insect repellants at this time. The clinician should be alerted to the fact that such a relationship may exist, and consider DET exposure in children presenting with a bizarre neurologic illness similar to the one presented in this paper.
Valproic acid-induced abnormal behavior
Indian Journal of Psychiatry, 2010
last six weeks. Her past medical history revealed that 14 weeks ago she was hospitalized following three episodes of seizures in a day with up rolling of eyeballs, confusion and limbs stiffness. A diagnosis of complex partial seizure with secondary generalized seizure disorder was made. She was treated with tablet valproic acid 200 mg twice daily and tablet clobazam 5mg at night during her hospital stay. After 5 days of treatment she was discharged with refilled prescription of valproic acid and clobazam and advised for monthly visits. Patient was otherwise normal and had no known psychiatric history or previous episodes of abnormal behavior. After 13 weeks of treatment with valproic acid and clobazam, she was hospitalized with complaints of irrelevant talk, talking to self, wandering and singing devotional songs, decreased food intake and insomnia since about five weeks i.e. about eight weeks after initiation of valproic acid therapy. Upon hospitalization, tablet chlorpromazine 100mg once daily, tablet olanzapine 5mg thrice daily, tablet risperidone 3mg twice daily were started while she continued to receive valproic acid and clobazam at the same dose. She was discharged on day three of hospitalization with an advice to continue all medications prescribed during the hospital stay at same doses for 15 days. However, her complaints of wandering, insomnia and decreased food intake continued to
International Journal of Research in Medical Sciences, 2016
Stevens Johnson syndrome is a life threatening IgE mediated hypersensitivity reaction affecting the skin and mucous membranes and should be considered in any child who has been on antiepileptic medication. A case of Stevens Johnson Syndrome and hepatitis following treatment with sodium valproate is presented. A 2 year old female pediatric patient suffering from atonic seizures and myoclonic seizures was treated with sodium valproate monotherapy. The patient reported skin peeling and rash since 15 days and yellowish discoloration of sclera since 7 days. Her laboratory investigations revealed abnormal hemoglobin levels, blood urea and liver function. Based on physical examination and laboratory findings it was diagnosed that she was suffering from sodium valproate induced Stevens Johnson Syndrome with hepatitis. The score of toxic epidermal necrosis (SCORTEN) criteria score was 1. She was treated with antihistamines, iron folic acid and topical liquid paraffin lotion.
Anemia secondary to valproic acid therapy in a 13-year-old boy: a case report
Journal of Medical Case Reports, 2012
Introduction: Valproic acid is a commonly used anti-epileptic drug. Hematological toxicities are among the occasionally observed adverse effects of this medication. Case presentation: We present the case of a 13-year-old Caucasian boy who demonstrated mild anemia 12 months after the introduction of valproic acid therapy. A bone marrow biopsy revealed maturation arrest of proerythroblasts. Conclusion: Prompt diagnosis and valproic acid discontinuation resulted in the patient's recovery.