Priming and Inhibitory Effects of Glucose on Insulin Secretion from Perifused Rat Islets of Langerhans (original) (raw)
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A Comparison of Vitamin D Levels in Nondiabetic and Diabetic Patient Populations
Journal of the American Podiatric Medical Association, 2009
The human skeleton is a rigid framework providing the foundation upon which we are able to ambulate and move and lift objects. Despite the fact that the skeletal system is a static source of strength and mobility, the bony architecture is a dynamic entity constantly being remodeled and reshaped in response to stresses and challenges placed on the skeletal system. The metabolic state of bone is a complex network of physiologic, biomechanical, and histologic systems working synergistically to maintain a balance between bone loss and bone production.
Correlation of serum vitamin D with hip fracturesin males more than 50 years of age
International Journal of Medical Research and Review, 2015
Introduction: Vitamin D is vital for bone health because it assists in the absorption and utilization of calcium. There are various studies in elderly females with hip fractures correlating the Vitamin D levels. But very few studies have evaluated the serum Vitamin D levels in males more than 50 years. Materials and Methods: Present study was conducted in the JIPMER Pondicherry between August 2012 and August 2013. A total of 41 male patients aged more than 50 years with fracture neck of femur and Intertrochanteric fracture were included. Blood samples were taken stored, processed and evaluated for vitamin D total (D2 and D3). The Values of Vitamin D obtained are shown into three groups as 0-20ng/ml-deficiency, 20-30ng/ml as insufficiency and>30ng/ml as normal Reference. Results: On analysis of Vitamin D we found that out of total 41 patients 9(22%) had vitamin D level <20ng /ml, 15(36%) had levels between 20ng-30ng/ml and 17 (41%) had >30ng/ml. Of the 21 patients with Neck of femur fractures Vitamin D<20ng/ml are 6(28.6%),20-30ng/ml are 9 (42.9) and >30ng/ml are 6(35.3).Vitamin D levels in 20 intertrochanteric fractures are<20ng/ml in 3(15%), 20-30ng/ml in 6(35%) and >30ng/ml in 11(55%). Conclusion: We found 24 patients (58%) have vitamin D level <30ng/ml, more in patients with neck femur fracture than intertrochanteric fractures. Present study found that there is no statistically significant correlation between the vitamin D level and proximal femoral fractures in elderly males (p=0.489).
Family Medicine & Primary Care Review, 2019
Background. orthopaedic fractures are one of the common presentations among elderly patients at any primary care facility. While most researches have labelled osteoporosis as being responsible for these fractures in the elderly, vitamin d deficiency, despite being prevalent in all races, age groups and ethnic backgrounds, is given lesser importance. Objectives. To assess vitamin d level and its relation with advancing age among older adults presenting with an orthopedic fracture. Material and methods. A cross-sectional study was performed at one of the orthopaedic oPd, in tertiary care hospital from North india. The patients 45 years and above presenting with orthopaedic fracture were eligible and out of whom 102 were included in the study. For assessing vitamin d level, we measured serum 25(oH)d level, taking cutoff for deficiency, insufficiency and normal levels at < 10, 10-29 and 30 ng/ml or more respectively. Results. out of 102 elderly patients we selected, 59% were male and 41% were females, with the mean age of 61 ± 13.4 years. Majority of them (94.2%) had low serum vitamin d levels. We observed lower levels of vitamin d level to be significantly associated with higher age, menopausal females and no sunlight exposure. Conclusions. With almost all older patients with fracture had low vitamin d levels and its high association with advancing age, we recommend to screen all people for vitamin d deficiency, starting middle age and proper management to prevent fracture in elderly.
International Journal of Research in Orthopaedics, 2018
Background: Proximal femoral fractures are very common in elderly patients. These fractures are thought to be associated with osteoporosis. Vitamin D is a possible risk factor for osteoporosis. So, this study was done to evaluate the association of serum vitamin D level with types of femoral fractures in elderly patients.Methods: The study was done between September 2013 to August 2016, 75 patients with age >60 years (male and female both) with proximal femoral fractures were studied. Serum 25-hydroxy vitamin D, calcium, phosphate, alkaline phosphatase levels, liver function test, renal function test, hemoglobin and complete blood counts of all the patients were assessed.Results: On assessment of serum vitamin D in proximal femoral fracture in elderly patients, it shows an increase incidence of proximal femoral fractures in patients with low serum vitamin D level. Fracture of neck of femur was most common among all. Type of fracture has no significant statistical relationship wit...
Vitamin D deficiency as a risk factor for osteoporotic fractures
Bone, 2008
The evidence on the association between vitamin D deficiency and fracture incidence is contradictory. Therefore, the objective of this study was to examine whether low serum 25-hydroxyvitamin D (25(OH)D) levels are associated with osteoporotic fractures.
Journal of Orthopaedic Surgery
Background: Data of vitamin D sufficiency in Asian patients with osteoporotic fragility hip fractures are limited. This study aimed to obtain data from the Japanese population. Methods: Patients aged 60 years or older with hip fractures were prospectively enrolled. Serum 25-hydroxyvitamin D (25(OH)D) levels were measured. Levels were compared between patients receiving and not receiving treatment for osteoporosis, those with and without previous contralateral hip fractures, and those with femoral neck versus trochanteric fractures. Sex-based differences were also assessed. The serum levels in patients younger than 60 years with extremity fractures were assessed, and differences between elderly and younger patients were evaluated. The individual correlation between 25(OH)D levels and the ultraviolet (UV) index and age was analyzed in elderly patients with hip fractures. Results: The data of 360 patients (aged 84.7 ± 8.2 years), comprising 80 men and 280 women, were analyzed. The mean...
Hip Fractures and Bone Mineral Density in the Elderly—Importance of Serum 25-Hydroxyvitamin D
PLoS ONE, 2014
Background: The significance of serum 25-hydroxyvitamin D [25(OH)D] concentrations for hip fracture risk of the elderly is still uncertain. Difficulties reaching both frail and healthy elderly people in randomized controlled trials or large cohort studies may in part explain discordant findings. We determined hazard ratios for hip fractures of elderly men and women related to serum 25(OH)D, including both the frail and the healthy segment of the elderly population.
Is Vitamin D deficiency an endangerment for Fracture?
Surgical Update: International Journal of Surgery and Orthopedics
Introduction: The incidence of fragility hip fracture is on a step increase. Vitamin D is essential for the growth and development of the bone. The decrease in the exposure to sun's radiation leads to this deficiency causing a global threat. There were many studies pointing towards Vitamin D deficiency as a risk factor for fracture. However, the relationship between serum Vitamin D and bone mineral density (BMD) in the senile osteoporotic fracture is still unclear. The aim of this study is to find out whether Vitamin D deficiency is a risk factor for fragility fracture. Method: It is a prospective study done at Sri Ramachandra Medical College Chennai and Velammal Medical college Madurai between Jan 2017 to Dec 2019. The inclusion criteria were male patients age more than seventy and female patients more than sixty presented with fragility hip fractures. The group I was the cases, patients with hip fractures. The group II was the age and gender-matched control. All the patients included in the study underwent both Vitamin D 25 OH and Dexa scan. The current study had 56 patients in group I as cases and 54 patients in group II as control. Results: The mean value of vitamin D 25OH in fracture patient group I was 19.85 and the age and gender-matched control group was 26.09. The current study had totally seventy-nine patients in the study who were either Vitamin D deficient or insufficient. The present study had 16 cases patient and 15 controls who were having sufficient level vitamin D. Conclusion: Vitamin D has no role in fracture prevention and certainly Vitamin D deficiency is not an endangerment for fractures.