Cost Effectiveness Analysis of Antihypertensive Drugs Usage by Combination of ACEI – CCB And ACEI – Diuretic in Outpatient Hypertension Therapy at Mintohardjo Navy Hospital Jakarta Period July-November 2015 (original) (raw)

Hypertension is one of the silent killer diseases influenced by many factors. The prevalence of hypertension in Indonesia is 7.6 % in 2013 and then increased to 9.5%. This study aimed to determine the drug effectiveness and cost-efficiency in the treatment of hypertension patients who use antihypertensive drugs combinations (ACEI-CCB and ACEI-Diuretic) at outpatient unit Mintohardjo Navy Hospital Jakarta during period from June to November 2015. This study was a cohort design to measure the cost effectiveness of antihypertensive drugs combination ACEI-CCB and ACEI-Diuretic. The data were collected prospectively from medical record of outpatient hypertension visiting Mintohardjo Navy Hospital, Jakarta. The samples size was 200 patients with hypertension who meet the inclusion and exclusion criteria and divided into 2 groups. Group 1 was 100 hypertension patients using antihypertensive drugs combination ACEI-CCB and group 2 with the combination of ACEI-Diuretic. Both groups of patients who get antihypertensive drugs combination followed and observed for 3 months for each patient. The drug's effectiveness is measured by counting the number of patients having blood pressure in under control (<140/90 mmHg) and 130/80 mmHg for patients with diabetes mellitus. Cost efficiency is measured on the basis of the unit cost of each group and the value of the ratio of cost effectiveness. The results showed that the greatest effective therapetic of drug found in the combination of ACEI-CCB marked by the patient's controlled blood pressure was 98%, whereas the controlled blood pressure in the group of ACEI-Diuretic patients was only 91%. Efficiency found in the Group ACEI-Diuretic marked by the lowest unit cost of IDR 1.073.848, whereas in the Group of ACEI-CCB of IDR 1.096.790. The antihypertensive drugs combination ACEI-CCB is more effective than ACEI-Diuretic combination. The antihypertensive drug combination ACEI-Diuretik is more efficient than ACEI-CCB combination