Impact of baseline adipose tissue characteristics on change in adipose tissue volume during a low calorie diet in people with obesity—results from the LION study (original) (raw)
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2012
Previous cross-sectional studies found that a single magnetic resonance imaging (MRI) slice predicts total visceral and subcutaneous adipose tissue (VAT and SAT) volumes well. We sought to investigate the accuracy of trunk single slice imaging in estimating changes of total VAT and SAT volume in 123 overweight and obese subjects who were enrolled in a 24-week CB-1R inverse agonist clinical trial (weight change, −7.7±5.3 kg; SAT change, −5.4±4.9 L, VAT change, −0.8±1.0 L). VAT and SAT volumes at baseline and 24 weeks were derived from whole body MRI images. The VAT area 5-10 cm above L 4 -L 5 (A +5-10 ) (R 2 =0.59-0.70, P<0.001) best predicted changes in VAT volume but the strength of these correlations were significantly lower than those at baseline (R 2 =0.85-0.90, P<0.001). Furthermore, the L 4 -L 5 slice poorly predicted VAT volume changes (R 2 =0.24-0.29, P<0.001). Studies will require 44-69% more subjects if (A +5-10 ) is used and 243-320% more subjects if the L 4 -L 5 slice is used for equivalent power of multi slice total volume measurements of VAT changes. Similarly, single slice imaging predicts SAT loss less well than cross-sectional SAT (R 2 =0.31-0.49 vs. R 2 =0.52-0.68, p<0.05). Results stayed the same when examined in men and women separately. A single MRI slice 5-10 cm above L 4 -L 5 is more powerful than the traditionally used L 4 -L 5 slice in detecting VAT changes, but in general single slice imaging poorly predicts VAT and SAT changes during weight loss. For certain study designs, multi-slice imaging may be more cost effective than single slice imaging in detecting changes for VAT and SAT.
Standardized assessment of whole body adipose tissue topography by MRI
Journal of Magnetic Resonance Imaging, 2005
Purpose: To assess standardized whole body adipose tissue topography in a cohort of subjects at an increased risk for type 2 diabetes and to compare fat distribution in subgroups regarding anthropometric (age, body mass index [BMI]) and metabolic parameters (insulin sensitivity).
Clinical Radiology, 2020
To compare the changes in visceral adipose tissue (VAT), liver fat fraction, and liver stiffness using quantitative magnetic resonance imaging (MRI) during a very-low-calorie ketogenic (VLCK) diet and a standard low-calorie diet (LC). MATERIALS AND METHODS: The study involved secondary analysis of prospective collected clinical data. Patients undergoing weight loss interventions were randomised to either a LC or a VLCK diet. VAT, liver fat fraction, and stiffness were measured at baseline and after 2 months. RESULTS: Forty-six patients were included; 39 patients were evaluated at baseline and at 2 months follow-up. Mean weight loss was e9.7AE3.8 kg (interquartile range [IQR]: e12.3; e7 kg) in the VLCK group and e1.67AE2.2 kg (IQR: e3.3, e0.1 kg) in the LC group (p<0.0001). Mean VAT reductions were e39.3AE40 cm 2 (IQR: e52, e10 cm 2) and e12.5AE38.3 cm 2 (IQR:
Visceral fat loss induced by a low‐calorie diet: a direct comparison between women and men
Diabetes, Obesity and Metabolism, 2009
Aim: No studies have assessed if changes in visceral adipose tissue (VAT) during weight loss differ between women and men with comparable amounts of VAT at baseline. The aim of this study was to assess if changes in VAT induced by a low‐calorie diet (LCD) differ between women and men.Methods: In this post hoc analysis of an existing database, abdominal adipose tissue was evaluated before and after an 8‐week LCD (800–1000 kcal/day) by a single‐slice magnetic resonance scan performed at the abdominal level. Body composition was measured by dual X‐ray energy absorptiometry.Results: Data from 111 obese subjects (85 women and 26 men) were available. Relative changes in VAT were found to be more pronounced in men [mean (95% CI): −32.6% (−38.7 to −26.6)] than in women [−21.9% (−25.0 to −18.8)] (p = 0.003) after correction for relative changes in fat mass (FM). When analysing only the data from a subgroup of 23 women and 23 men who were matched for similar visceral to abdominal subcutane...
2019
Background and Objectives: Types and amounts of nutrients may influence the volume of subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT). This study targeted to investigate the relationship between SAT and VAT volumes and macroand micronutrients intake among adults. Methods and Study Design: Data were collected via a private face-toface interview, in which diet history was obtained using validated quantitative food frequency questionnaire. The different fat volumes were assessed using magnetic resonance imaging (MRI) scanning. Results: Participants with the lowest SAT volume had the highest intake of monounsaturated fatty acids (p<0.044) and omega-3 fatty acids (p<0.048). VAT volume was significantly associated with the highest level of total energy and energy from carbohydrate consumption among participants (p<0.037) while significantly associated with the lowest energy intake from fat among participants (p<0.013). There was a significant relationship w...
Circulation, 2017
Background -We aimed to assess whether distinct lifestyle strategies can differentially affect specific body adipose depots. Methods -We performed an eighteen-month randomized controlled trial among 278 sedentary adults with abdominal obesity (75%) or dyslipidemia in an isolated workplace with a monitored provided lunch. Participants were randomized to iso-caloric low-fat (LF) or Mediterranean/low-carbohydrate (MED/LC) diet+28g walnuts/day with/without added moderate physical activity (PA;80% aerobic; supervised/free gym membership). Overall primary outcome was body fat re-distribution, and the main specific endpoint was visceral adipose tissue (VAT). We further followed the dynamics of different fat depots [deep/superficial subcutaneous (D/SSAT), liver, pericardial, muscle, pancreas and renal-sinus] by magnetic-resonance-imaging. Results -Of 278 participants (age=48y; 89%men, body-mass-index=30.8kg/m2), 86% completed the trial, with good adherence. The LF group preferentially decre...
Journal of Obesity, 2011
Introduction. Subcutaneous fat (ScF) and visceral fat (VF) measurements using CT scan are expensive and may imply significant radiation doses. Cross-sectional studies using CT scan showed that ScF and VF are significantly correlated with abdominal fat measured by DXA (AF-DXA). The association has not been studied after a weight loss. Objective. To determine (1) the associations between AF-DXA and ScF and VF before and after weight loss and (2) the associations between their changes. Methods. 137 overweight/obese postmenopausal women were divided in two groups (1-caloric restriction or 2-caloric restriction + resistance training). AF was assessed using DXA and CT scan. Results. Correlations between AF-DXA and ScF (before: r = 0.87, after; r = 0.87; P < .01) and, AF-DXA and VF (before: r = 0.61, after; r = 0.69; P < .01) are not different before and after the weight loss. Correlations between delta AF-DXA and delta ScF (r = 0.72; P < .01) or delta VF (r = 0.51; P < .01) were found. Conclusion. The use of AF-DXA as a surrogate for VF after weight loss is questionable, but may be interesting for ScF.