Transformative Nano-Drug Delivery Strategies: Addressing Challenges in Modern Therapeutics (original) (raw)

Recent trends in nanotechnology-based drugs and formulations for targeted therapeutic delivery

Recent patents on inflammation & allergy drug discovery, 2016

In the recent past, a wider spectrum of nanotechnology-based drugs or drug-loaded devices/systems has been engineered and investigated though using different methodological approaches including in-vitro, in-vivo, and ex-vivo techniques. Among them, nanoparticles-based therapeutic agents have been exploited for an enhanced and efficient delivery in the current biomedical sector of the modern world. However, the development of new types of novel, efficient and highly reliable therapeutic drug delivery system (DDS) for multipurpose applications is essential and also a core demand to tackle many human health related diseases. Moreover, this could also be helpful for an enhanced/better quality of patient life in a more secure way by avoiding/limiting drug abuse, or serious adverse effects of some in practice traditional therapies. In this context, nanotechnology-based several advanced DDS have been engineered with novel characteristics for biomedical, pharmaceutical and cosmeceutical app...

Innovative pharmaceutical development based on unique properties of nanoscale delivery formulation

Nanoscale, 2013

The advent of nanotechnology has reignited interest in the field of pharmaceutical science for the development of nanomedicine. Nanomedicinal formulations are nanometer-sized carrier materials designed for increasing the drug tissue bioavailability, thereby improving the treatment of systemically applied chemotherapeutic drugs. Nanomedicine is a new approach to deliver the pharmaceuticals through different routes of administration with safer and more effective therapies compared to conventional methods. To date, various kinds of nanomaterials have been developed over the years to make delivery systems more effective for the treatment of various diseases. Even though nanomaterials have significant advantages due to their unique nanoscale properties, there are still significant challenges in the improvement and development of nanoformulations with composites and other materials. Here in this review, we highlight the nanomedicinal formulations aiming to improve the balance between the efficacy and the toxicity of therapeutic interventions through different routes of administration and how to design nanomedicine for safer and more effective ways to improve the treatment quality. We also emphasize the environmental and health prospects of nanomaterials for human health care.

An overview on oral drug delivery via nano-based formulations

Pharmaceutical and Biomedical Research, 2018

Oral drug administration is used for a large number of medications, intended to create a systemic effect in the body. Over the recent years, an increasing attention has been directed by pharmacists toward the development of successful formulations for oral drug delivery. However, this issue is still controversial in pharmaceutical technology with many limitations due to the numerous barriers against the absorption and permeability in the gastrointestinal tract. On the other hand, drug carriers play an important role in providing prolonged release and delivery and overcome the multiple barriers of maintaining appropriate bioavailability. Nano scaling of the particles, carriers, and polymers has also provided the capability to characterize and control materials in order to produce unique pharmaceutical components and structures. Furthermore, personalized healthcare, rational drug design, and site-specific targeted drug delivery are some of the profits gained from a nano-based formulat...

New Aspects of Nanopharmaceutical Delivery Systems

Nanobiotechnology, involving biological systems manufactured at the molecular level, is a multidisciplinary field that has fostered the development of nanoscaled pharmaceutical delivery devices. Micelles, liposomes, solid lipid nanoparticles, polymeric nanoparticles, functionalized nanoparticles, nanocrystals, cyclodextrins, dendrimers, nanotubes and metallic nanoparticles have been used as strategies to deliver conventional pharmaceuticals or substances such as peptides, recombinant proteins, vaccines and nucleotides. Nanoparticles and other colloidal pharmaceutical delivery systems modify many physicochemical properties, thus resulting in changes in the body distribution and other pharmacological processes. These changes can lead to pharmaceutical delivery at specific sites and reduce side effects. Therefore, nanoparticles can improve the therapeutic efficiency, being excellent carriers for biological molecules, including enzymes, recombinant proteins and nucleic acid. This review discusses different pharmaceutical carrier systems, and their potential and limitations in the field of pharmaceutical technology. Products with these technologies which have been approved by the FDA in different clinical phases and which are on the market will be also discussed.

Role of Nanotechnology in Drug Delivery

2017

Nanotechnology is an emerging field, comprising the development of materials with 5-200 nanometers in size. Like many other fields advances in nanotechnology is utilized in medicine also specially for therapeutic drug delivery and treatment for a variety of diseases and disorders. The drug is dissolved and entrapped into biodegradable nanoparticles which are specially designed to absorb drug and protecting it against chemical and enzymatic degradation. Nanotechnology is helping the delivery of pharmacologically active molecules for sitespecific action with accurate dose. The most promising aspect of utilizing nanotechnology in drug delivery system is lowering of side effects by depositing the active agent in the morbid region only with accurate dose. Nanoparticles for drug delivery are prepared by a variety of materials such as proteins, polysaccharides and synthetic polymers. The selection of material depends on many factors such as the size of nanoparticles, inherent properties of...

Recent Trends of Nanotechnology In Drug Delivery And Their Application-An Overview

Controlled drug delivery systems (DDS) have several advantages compared to the traditional dosage forms. From the last few decades, there has been a considerable research on the basis of Novel drug delivery system, using particulate drug delivery systems as such drug carriers for small and large molecules. Nanoparticles, Liposomes, Microspheres, Niosomes, Pronisomes, Ethosomes, and Pro-liposomes have been used as drug carrier in vesicle drug delivery system. Various polymers have been used in the formation of Nanocarriers. Nanocarriers are colloidal particulate systems with size ranging between 10-1000 nm. This are used for the diagnosis, treatment and monitoring of various diseases and physical approach to alter and improve the pharmacokinetic and pharmacodynamics properties of various types of drug molecules. Controlled and targeted delivery is one of the most valuable requirements from a carrier, which involves multidisciplinary site specific or targeted approach. Nanoparticulate drug delivery system may offer plenty of advantages over conventional dosage forms, which includes improved efficacy, reduced toxicity, enhanced biodistribution and improved patient compliance.

Nanomedicine: A New Frontier in Drug Delivery Systems

2024

The chapter explores the transformative potential of nanomedicine in revolutionizing drug delivery. Nanomedicine, combining nanotechnology and medicine, offers innovative solutions for healthcare. It delves into advancements enabling targeted and controlled release of therapeutics, improving treatment efficacy while reducing side effects. Beginning with an introduction to nanomedicine’s applications, it discusses recent breakthroughs such as nanoparticle-based delivery systems and targeted therapy nanocarriers. Real-world case studies illustrate nanomedicine’s efficacy across various diseases. Addressing challenges in translation to clinical practice, including safety and regulatory hurdles, it emphasizes collaborative efforts among stakeholders. Looking forward, ongoing research for safer and more efficient drug delivery systems is highlighted, stressing the need for continued innovation. The chapter aligns with the book’s theme of showcasing cutting-edge biomedical developments to improve healthcare.

NanoDDS 2013: The 11th International Nano Drug Delivery Symposium

Journal of controlled release : official journal of the Controlled Release Society, 2014

Nano-scale drug delivery systems (NDDSs) are both very important and very special. They are important because they are being applied to the most challenging diseases facing the world, including cancer, cardiovascular diseases, and infectious diseases. NDDSs are special because they alter biodistribution, pharmacokinetics, and pharmacodynamics in ways that cannot be achieved using traditional therapeutics. The size scale of these NDDSs ranges from a few nm up to several hundreds of nm. The molecular weight (or size) and biodegradability of the nanocarrier are both very important to its eventual clearance from the body. A nanocarrier may consist of a drug conjugated to a polymer (e.g., polyethylene glycol (PEG), poly(N-2-hydroxypropyl methacrylamide) (PHPMA)) or to a nanoparticle (gold, silica, carbon nanotubes), or complexed within polymer or lipid nanoparticles in a number of ways: ionically to a species of the opposite charge (e.g., polyplexes, lipoplexes), by hydrophobic forces (albumin, micellar, and liposomal membranes), or by aqueous solubility (within liposomes). The nanocarrier may also be biologically ('actively') targeted to specific cells using ligands (monoclonal antibodies, peptide ligands, metabolites) or physically ('passively') targeted to tumors via leaky blood vessels (enhanced permeability and retention effect, EPR). More recently, nano-scale features are becoming increasingly important in the development of local therapies, which include drug depots, stents, regenerative medicines, and other devices. Most clinically approved NDDS formulations have been designed for treating cancer; however, technologies are also being developed to treat a range of other chronic and life-threatening diseases. The topics covered by this special issue are an excellent representation of the diversity both in disease targets as well as in technology (Table 1). Many of these systems are composed of water-soluble and hydrophilic polymers, although they may be copolymerized with hydrophobic components. Some newer approaches utilize inorganic nanoparticles as well.

Nano Medicine: An Emerging Trend in Molecular Delivery

Journal of Drug Delivery and Therapeutics

Nanobiopharmaceuticals has involved, understanding issues related to target specific drug delivery. Previously the traditional dosage forms showed a greater difficulty in achieving bioavailability and therapeutic index. So addition of various functionalities to nano size materials interfacing them into various biological molecules has improved the drug delivery. Integration of nanomedicinals with biotechnology has brought a radical change in the research field both in vivo and invitro. It has paved the way to new therapies, surgical interventions and advanced drug delivery systems. Nanoparticles as nanomedicines opens the potential for crossing various biological barriers within the body especially the potential to cross the blood brain barrier may open new ways for drug delivery into the brain. Nanoparticles as drug delivery systems can be designed to improve the pharmacological and therapeutic properties of the drug. This manuscript has emphasized various nanobiopharmaceuticals in the field of cancer therapy, regenerative medicine, drug delivery, diagnostic devices, gene therapy and tissue engineering.