The Regulated Expression, Intracellular Trafficking, and Membrane Recycling of the P2Y-like Receptor GPR17 in Oli-neu Oligodendroglial Cells (original) (raw)

2013, Journal of Biological Chemistry

Background: GPR17 is a key player in oligodendrocyte differentiation. By regulating the availability of receptors at the cell surface, agonist-induced GPR17 trafficking may influence terminal cell fate. Results: UDP-glucose and LTD 4 induce GPR17 endocytosis and distribution in lysosomes or recycling compartments. Conclusion: Agonist-activated GPR17 undergoes partial degradation and fast membrane recycling. Significance: Understanding GPR17 trafficking may increase our knowledge of oligodendrocyte differentiation and myelination.

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