Self-Assembly of Metal–Virus Nanodumbbells (original) (raw)
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Bottom-up self-assembly methods in which individual molecular components self-organize to form functional nanoscale patterns are of long-standing interest in the field of materials sciences. Such self-assembly processes are the hallmark of biology where complex macromolecules with defined functions assemble from smaller molecular components. In particular, plant virus-derived nanoparticles (PVNs) have drawn considerable attention for their unique self-assembly architectures and functionalities that can be harnessed to produce new materials for industrial and biomedical applications. In particular, PVNs provide simple systems to model and assemble nanoscale particles of uniform size and shape that can be modified through molecularly defined chemical and genetic alterations. Furthermore, PVNs bring the added potential to "farm" such bio-nanomaterials on an industrial scale, providing a renewable and environmentally sustainable means for the production of nano-materials. This...
Viruses tend to be given a negative connotation due to their nature and the diseases they are known to carry. If you look past their malicious behavior, it is easy to see that nature has provided us a means to solve one of medicine’s most challenging aspects – effective, localized drug delivery. Therapeutics have made a great deal of headway since their first introduction, but sadly we still fall short when it comes to the two aforementioned issues. Virus-like particles such as the Qβ capsid allow us to tackle this issue head on by utilizing the non-infectious versions of a parent virus as a vessel we can load cancer drugs into and further functionalize to suit our intended goals. We seek to use the Qβ capsid, which upon self-assembly in its E.coli host system, encapsulates random tangles of mRNA. This allows us to use intercalating therapeutics such as Doxorubicin, which can be bound reversibly to the RNA inside through simple diffusion of the small molecule through any of the 32 p...
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Bottom-Up-Assembled Nanostar Colloids of Gold Cores and Tubes Derived From Tobacco Mosaic Virus Twinkle, twinkle little star: Directed selfassembly of bioinorganic hybrid nanostars with a high protein surface area was achieved by encapsidating immobilized RNA on metal beads with a plant viral protein. The selectivity of RNA hybridization to oligodeoxynucleotides exposed on the gold allowed the simultaneous fabrication of star colloids with distinct predetermined arm-length distributions in single-batch processes.
Virology, 2014
Due to the nanoscale size and the strictly controlled and consistent morphologies of viruses, there has been a recent interest in utilizing them in nanotechnology. The structure, surface chemistries and physical properties of many viruses have been well elucidated, which have allowed identification of regions of their capsids which can be modified either chemically or genetically for nanotechnological uses. In this review we focus on the use of such modifications for the functionalization and production of viruses and empty viral capsids that can be readily decorated with metals in a highly tuned manner. In particular, we discuss the use of two plant viruses (Cowpea mosaic virus and Tobacco mosaic virus) which have been extensively used for production of novel metal nanoparticles (o 100 nm), composites and building blocks for 2D and 3D materials, and illustrate their applications.