A tin-119 Mössbauer study of some disulphoxide complexes of triphenyltin(IV) chloride (original) (raw)
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Tripropyltin(IV) Complexes with some Selected Bioligands in 50 % V/V Dioxane/Water Mixture
Annali Di Chimica, 2006
The interaction of the tri-n-propyltin(IV) (TPT) with some selected bioligands having a variety of model functional groups were investigated using potentiometric technique at 25 °C and 0.1 M ionic strength in 50 % v/v dioxane/water mixture. TPT is hydrolyzed to give [(C3H7)3SnOH], [(C3H7)3Sn(OH)2]−, and [((C3H7)3Sn)2OH]+. Amino acids and DNA constituents form 1:1 and 1:2 complexes. Peptides form 1:1 complexes and the corresponding deprotonated amide species. The protonated complexes are formed with amino acids, peptides and some DNA constituents. The hydrolysis constants and the stepwise formation constants of the complexes formed in solution were calculated using the nonlinear least-square program MINIQUAD-75. The participation of different ligand functional groups in binding to organotin is discussed. The speciation diagrams of the various complex species were evaluated as a function of pH.
Journal of Coordination Chemistry, 2020
The triphenyltin(IV) complex of composition [Ph 3 Sn(3,5-(NO 2) 2 C 6 H 2 (OH)CONHO)] (1) has been synthesized by the reaction of Ph 3 SnCl with potassium 3,5-dinitrosalicylhydroxamate [3,5-(NO 2) 2 C 6 H 2 (OH)CONHOK] and characterized by physicochemical studies, spectroscopic techniques (IR, 1 H 13 C, and 119 Sn NMR), and mass spectrometry. The electrochemical behavior of ligand and 1 have been studied by cyclic voltammetry. The thermal behavior of 1 has been studied by thermogravimetric techniques (TGA, DTG, and DTA) and various kinetic parameters have been calculated. The optimized geometry of 1 was computed by the DFT method using B3LYP/631-G Ã set. The vibrational frequencies, 1 H and 13 C NMR spectra have been computed and compared with the experimental data. The global descriptors have been calculated. The various thermodynamic parameters, Gibbs free energy (G), enthalpy (H), entropy (S), bond energy (E), constant heat volume capacity (C v), internal energy (U), and dipole moment (m) have been calculated. The in vitro antimicrobial activity assay against pathogenic gram-(À) bacteria viz. Salmonella typhi, Escherichia coli; gram-(þ) bacteria Bacillus cereus and Staphylococcus aureus; and fungi Fusarium sambucinum and Rhizoctona solani by MIC method; the in vitro cytotoxicity on human muscle rhabdomyosarcoma (RD) by MTT method and the antioxidant potential by DPPH free radical scavenging showed higher inhibitory effect of 1 than ligand.
Molecular mechanism of haemolysis induced by triphenyltin chloride
Applied Organometallic Chemistry, 2002
Organometals are known to cause lysis of cells, but the molecular mechanism of their action is not recognized. In this work, we have examined the interaction of triphenyltin with erythrocyte membranes. We determined the order of haemolytic activity of the investigated organometal species as being: triphenyllead > tripropyltin = triphenyltin > triethyllead > trimethyltin. Such an order suggests that the haemolytic activity increases with the increasing hydrophobicity of the organic ligands. Compounds containing lead are more toxic than the respective complexes of tin. Triphenyltin chloride (Ph3SnCl) is very effective in lysis of erythrocytes. Using 119Sn Mössbauer spectroscopy we showed that triphenyltin interacts with the protein components of pig erythrocyte membranes in a highly specific way, but we did not detect any interaction of triphenyltin with pig haemoglobin. The Mössbauer spectrum was fitted with a single doublet characterized by hyperfine parameters that differ ...