Production of very large sized scaffold-free engineered cartilage constructs from the adult equine donor – a basis for therapeutic and experimental applications in the horse (original) (raw)
Related papers
Modeling of articular cartilage replacement materials
Archives of Mechanics, 2009
The development of replacement material for human articular cartilage exhibiting similar mechanical properties as the native tissue is a problem of high actuality in biomedicine. In the present work a new condensed collagen material is investigated. The study aims at developing a mechanical model especially adapted to this particular collagen material. For this purpose, a viscoelastic-diffusion (VED) model is proposed, accounting for two different diffusion evolutions assumed. Moreover, the need for a gradient material description is discussed in order to cover fabrication influences leading to a variable Young's modulus for the material. On this background, a phenomenological law is presented to predict deformation-dependent diffusion behavior and internal reaction forces. Furthermore, the present approach allows a practible identification of diffusion parameters. The theoretical model is implemented into a finite element code and parameters are identified by tension tests. The simulation results are validated experimentally.
Loading Preview
Sorry, preview is currently unavailable. You can download the paper by clicking the button above.