Niosomes as an Emerging Formulation Tool for Drug Delivery-A Review (original) (raw)

NIOSOMES AS AN EMERGING FORMULATION TOOL FOR DRUG DELIVERY-A REVIEW Review Article

International Journal of Applied Pharmaceutics, 2019

Nonionic surfactant based vesicles which are uni/multilamellar in structures are called niosomes. These vesicles contains an aqueous interior surrounded by one or more amphiphilic bilayer membrane forming surfactant which separates them from the bulk solution, and are also called as supramolecular aggregates. Niosomes, being an efficient drug delivery system, investigations are carried out to utilize this system to treat various disorders, to promote improved patient compliance, lesser side effects, reduction in dose, lesser dosage frequency, and higher amount of the drug at the particular site so as to lessen an excessive contact with the whole body. The Pharmacokinetic and Pharmacodynamic profile of Niosomal drug delivery system vary for various entrapped drugs. Drugs that are successful in the mitigation or treatment of CNS disorders should cross the BBB to reach the brain, as BBB seems to be an obstacle for a large number of drugs, including CNS active drugs. This article compiles recent techniques for the preparation and characterization of niosomes, the effect of formulation variables on its physicochemical properties and discussed about its effective applications in drug delivery.

Niosome: A Promising Nanocarrier for Natural Drug Delivery through Blood-Brain Barrier

Advances in Pharmacological Sciences

Niosomes (the nonionic surfactant vesicles), considered as novel drug delivery systems, can improve the solubility and stability of natural pharmaceutical molecules. They are established to provide targeting and controlled release of natural pharmaceutical compounds. Many factors can influence on niosome construction such as the preparation method, type and amount of surfactant, drug entrapment, temperature of lipids hydration, and the packing factor. The present review discusses about the most important features of niosomes such as their diverse structures, the different preparation approaches, characterization techniques, factors that affect their stability, their use by various routes of administration, their therapeutic applications in comparison with natural drugs, and specially the brain targeting with niosomes-ligand conjugation. It also provides recent data about the various types of ligand agents which make available active targeting drug delivery to the central neuron syst...

A review on Niosomes: Recently tested drugs and their application in different treatment

2021

Niosomes are self-assembly vesicular nano-carriers produced by the hydration of surfactants, cholesterol or different amphiphilic moiety. These all components provides flexible delivery of drugs with a range of applications vary from dermal to brain-targeted delivery. Niosomes are the proficient carrier for the water insoluble drugs enhance their solubility and efficacy. In this review we summarise the basic details of niosomes such as their advantages, disadvantages, composition, factor that affect niosomes formulation, method of preparation, evaluation parameters and some recently studied application of niosmes for various treatment. Keyword: Niosome, method of preparation, factor affecting formulation, Evaluation parameter, Recently tested drugs. Introduction Niosomes are a vesicular, novel drug delivery system that helps to release the drugs in a sustained, regulated, and targeted manner [1,2 ]. Firstly liposomes were prepared to provide the vesicular drug delivery system due to...

Pharmaceutical Niosomes Drug Delivery: A Complete Review of New Delivery System

IJRDO-Journal of Applied Science

Over the past ten years, people working in the field of drug delivery systems have become increasingly interested in designing vesicles as a tool to improve drug delivery. A hydrating mixture of cholesterol and nonionic surfactants forms niosomes, which are vesicles. Liposomes, microspheres, engineering science,small emulsions, antibody loaded drug delivery , magnetic microcapsules,implantable pumps, and niosomes are just a few of the unique methods employed to administer these medications. There are two requirements before designing and developing a novel drug delivery system (NDDS). It must first spread the medication at a preset rate and then release an amount of medication at the site of action that is therapeutically efficacious. These requirements cannot be satisfied by conventional dose forms. In essence, niosomes are non-ionic surfactant-based vesicles in which a group of surfactant macromolecules forms a bilayer to form a membrane that entirely seals off an aqueous solut...

A Novel Drug Delivery System: Niosomes Review

Drug targeting is a kind of mechanism in which the drug is administered in the body in such a way that the drug interacts at a cellular or subcellular level with the target tissue to achieve a desired therapeutic response at a desired location without unwanted interactions at other sites. This can be done by modern methods such as niosomes, which target the drug delivery system. Niosomes are the type of non-ionic surfactant vesicles which are a new approach to liposomes that is biodegradable, non-toxic, more durable and cheaper. Their liposome-like structure and therefore they can represent alternate vesicular structures in relation to liposomes. The niosomes appear to load various types of drugs. This review article describes niosome structure, benefits, drawbacks, niosome preparation methods and pharmaceutical NSV characterisation.

Niosomes : as novel vesicular drug delivery system

2018

Target-specific drug-delivery systems for the administration of pharmaceutical compounds enable the localization of drugs to target sites within the body. The basic component of drug delivery systems is an appropriate carrier that protects the drug from rapid degradation or clearance and thereby enhances drug concentration in target tissues. Niosome are microscopic non-ionic surfactant bilayer vesicles obtained on hydration of synthetic nonionic surfactants, with or without incorporation of cholesterol or their lipids. The amphiphilic nature of niosomes promotes their efficiency in encapsulating lipophilic or hydrophilic drugs. Noisome are promising vehicle for drug delivery and being non-ionic, more stable, inexpensive, biodegradable, biocompatible, non immunogenic and exhibit flexibility in their structural characterization. Various additives in niosomes include nonionic surfactant as film forming agent, cholesterol as stabilizing and rigidizing agent for the bilayer and various c...

Niosomal Drug Delivery - A Comprehensive Review

Asian Journal of Pharmaceutics, 2018

Niosomes or non-ionic surfactant vesicles are microscopic lamellar structures formed on admixture of non-ionic surfactant of the alkyl or dialkyl polyglycerol ether class and cholesterol with subsequent hydration in aqueous media. They are vesicular systems similar to liposomes that can be used as carriers of amphiphilic and lipophilic drugs. The basic process of preparation is the same, i.e., hydration by aqueous phase of the lipid phase which may be either a pure surfactant or a mixture of surfactant with cholesterol. After preparing niosomal dispersion, unentrapped drug is separated by dialysis centrifugation or gel filtration. A method of in vitro release rate study includes the use of dialysis tubing. Niosomes are promising vehicle for drug delivery, and being non-ionic, it is less toxic and improves the therapeutic index of the drug by restricting its action to target cells. Niosomes are unilamellar or multilamellar vesicles formed from synthetic non-ionic surfactants. They ar...

A Review on Niosomes: Potential Vesicular Drug Delivery System

Journal of Drug Delivery and Therapeutics

Over the years researchers have been making an attempt to improve the potency of utilization of medicament for treatment of numerous diseases. During this endeavour, drug delivery systems have helped greatly by achieving reduced dose, reduced dosage frequency, improved patient compliance, improved bioavailability and maximum concentration of the drug at the target site. Recent years have seen an unprecedented growth in the use of nanotechnology in designing drug delivery systems. Niosomes are vesicles composed of non-ionic surfactants, which are biodegradable, comparatively non-toxic, stable, economical and effective alternate to liposomes. This review is deepening and widening the interest of Niosomes in several scientific disciplines and notably its application in drug delivery. This review additionally presents a summary of the types, methods of preparation, characterization and applications of Niosomes. Keywords: Niosomes, types, method of preparation, factors affecting and app...

Niosomes: A Controlled and Novel Drug Delivery System

Biological & Pharmaceutical Bulletin, 2011

During the past decade formulation of vesicles as a tool to improve drug delivery, has created a lot of interest amongst the scientist working in the area of drug delivery systems. Vesicular system such as liposomes, niosomes, transferosomes, pharmacosomes and ethosomes provide an alternative to improve the drug delivery. Niosomes play an important role owing to their nonionic properties, in such drug delivery system. Design and development of novel drug delivery system (NDDS) has two prerequisites. First, it should deliver the drug in accordance with a predetermined rate and second it should release therapeutically effective amount of drug at the site of action. Conventional dosage forms are unable to meet these requisites. Niosomes are essentially non-ionic surfactant based multilamellar or unilamellar vesicles in which an aqueous solution of solute is entirely enclosed by a membrane resulting from the organization of surfactant macromolecules as bilayer. Niosomes are formed on hydration of non-ionic surfactant film which eventually hydrates imbibing or encapsulating the hydrating aqueous solution. The main aim of development of niosomes is to control the release of drug in a sustained way, modification of distribution profile of drug and for targeting the drug to the specific body site. This paper deals with composition, characterization/evaluation, merits, demerits and applications of niosomes.

Niosomes: A Unique Drug Delivery Tool

World Journal of Pharmacy and Pharmaceutical Sciences, 2014

Synthetic nonionic surfactants such as alkyl or dialkyl poly glycerol ether class when hydrated give niosomes. Niosomes are the drug carriers which provide substitute to liposomes and encapsulate the solutes in a way similar to liposomes. These may be unilamellar or multilamellar vesicles, present more in vitro stability and improved stability of drugs entrapped in comparison with the dosage forms which are conventional. [1] Niosomes can hold amphiphillic as well as lipophilic drugs and have the advantage of being biocompatible, biodegradable and non immunogenic over liposomes. Niosomes are used for targeted as well as controlled release for the treatment of many diseases including cancer, viral and other microbial diseases.