Indispensable Role of Indian Propolis and its Pharmacological Significance: A Review (original) (raw)
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Recent Studies in the Use of Propolis as a Traditional Medicine: A Review
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Propolis is formed by honey bees through mixing a quantity of wax into the resinous substances, which they create by mixing the plant secretions in the pollen baskets on their hind legs with enzymes in their saliva. Depending on the source from which it is obtained, propolis is found in a wide variety of colours, such as yellow, green, dark brown, being solid-state at room temperature. For centuries, apicultural products (such as honey, pollen, propolis, bee venom, bee bread and royal jelly) have been used in traditional medicine for treatment purposes. In recent years, biochemical studies related to propolis have focused on the antimicrobial, anti-inflammatory, antitumoral, and antioxidant activities of propolis.
Biological activity of bee propolis in health and disease
Asian Pacific journal of cancer prevention : APJCP
Propolis is a natural product derived from plant resins collected by honeybees. It is used by bees as glue, a general-purpose sealer, and as draught-extruder for beehives. Propolis has been used in folk medicine for centuries. It is known that propolis possesses anti-microbial, antioxidative, anti-ulcer and anti-tumor activities. Therefore, propolis has attracted much attention in recent years as a useful or potential substance used in medicine and cosmetics products. Furthermore, it is now extensively used in foods and beverages with the claim that it can maintain or improve human health. The chemical composition of propolis is quite complicated. More than 300 compounds such as polyphenols, phenolic aldehydes, sequiterpene quinines, coumarins, amino acids, steroids and inorganic compounds have been identified in propolis samples. The contents depend on the collecting location, time and plant source. Consequently, biological activities of propolis gathered from different phytogeogra...
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This review aims to analyze propolis as a potential raw material for the development and manufacture of new health-promoting products. Many scientific publications were retrieved from the Scopus, PubMed, and Google Scholar databases via searching the word "propolis". The different extraction procedures, key biologically active compounds, biological properties, and therapeutic potential of propolis were analyzed. It was concluded that propolis possesses a variety of biological properties because of a very complex chemical composition that mainly depends on the plant species visited by bees and species of bees. Numerous studies found versatile pharmacological activities of propolis: antimicrobial, antifungal, antiviral, antioxidant, anticancer, anti-inflammatory, immunomodulatory, etc. In this review, the composition and biological activities of propolis are presented from a point of view of the origin and standardization of propolis for the purpose of the development of new...
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Indian Journal of Natural Products and Resources, 2016
This study characterizes the antimicrobial, anti-oxidant properties and chemical profile of the propolis collected from the Shahapur region of Maharashtra. Chemical constituents were identified to be flavonoids, alkaloids, phytosterols, triterpenes and glycosides. Total phenolic content was 4.751 mg/g, while the protein content was 1.187 g percent. The anti-oxidant activity accounts to about 4.732 mM of ascorbic units, determined by phospho-molybdenum assay. Antimicrobial activities were tested on selected Gram-positive ( Staphylococcus aureus and Streptococcus pyogenes ) and Gram-negative ( Escherichia coli and Salmonella typhi ) bacteria, as well as on pathogenic fungi Candida albicans . Crude extracts in absolute ethanol was tested for in vitro anti-angiogenic activity by the CAM assay on fertilized Leghorn eggs. The anti-inflammatory test in terms of inhibition of hypotonicity-induced HRBC membrane lysis was determined to be 39.13 % at 8000 μg/mL. Results indicated that prop...
Nutrients
The use of alternative medicine products has increased tremendously in recent decades and it is estimated that approximately 80% of patients globally depend on them for some part of their primary health care. Propolis is a beekeeping product widely used in alternative medicine. It is a natural resinous product that bees collect from various plants and mix with beeswax and salivary enzymes and comprises a complex mixture of compounds. Various biomedical properties of propolis have been studied and reported in infectious and non-infectious diseases. However, the pharmacological activity and chemical composition of propolis is highly variable depending on its geographical origin, so it is important to describe and study the biomedical properties of propolis from different geographic regions. A number of chronic diseases, such as diabetes, obesity, and cancer, are the leading causes of global mortality, generating significant economic losses in many countries. In this review, we focus o...
Propolis: Properties, Application, and Its Potential
Evidence-Based Complementary and Alternative Medicine, 2013
Propolis is a honeybee product known for its biological and pharmacological properties for centuries. It has been extensively used in traditional medicine and also, because of its antibacterial, antiseptic, anti-inflammatory, and anesthetic activities, in complementary medicine. Propolis became subject of numerous studies developed and carried out all over the world in order to analyze its chemical composition as well as medicinal properties.
Oxidative Medicine and Cellular Longevity
Propolis is a well-known resinous natural substance collected by honeybees (Apis mellifera L.) from plants exudations. Variations in chemical composition of propolis are due to different sources from which it is collected and change in climate and geographical location. In this study, different propolis samples were collected from different regions of Balochistan and examined for its chemical composition, total phenolics and total flavonoid contents, and antioxidant potential by using DPPH radical scavenging assay and antimicrobial activity. Bioactive components analysis revealed the presence of steroids, carbohydrates, flavonoids, coumarins, cardiac glycosides, quinones, anthraquinones, terpenoids, tannins, and phlobatannins at different levels. The total phenolics contents were ranged from 2.9343 ± 1.247 to 6.0216 ± 2.873 mg GAE g-1, and flavonoid contents were found to be 0.1546 ± 0.087 to 0.6586 ± 0.329 mg QE g-1, respectively. The antioxidant ability of each extract was analy...
Editorial: Therapeutic potential of propolis—from in vitro studies to clinical trials
Frontiers in Pharmacology, 2023
Editorial on the Research Topic Therapeutic potential of propolis-from in vitro studies to clinical trials Propolis is a natural product made by bees from bioactive plant exudates and/or resins, which they employ to protect their colony health and integrity (Ghisalberti, 1979; Simone-Finstrom and Spivak, 2010). Taking their cue from the bees, man has been harvesting and using this product for thousands of years, across many civilizations, stimulated by empirical knowledge concerning its efficacy as a medically useful product (Berretta et al., 2020). More recently, the development of analytical methods and modern extraction processes has led to numerous studies regarding the chemical composition and diversity of propolis, and to a better understanding of its therapeutic properties (Bankova et al., 2019). There are numerous scientific publications showing the antimicrobial, antifungal, antiviral, anti-inflammatory, immunoregulatory, and other biological properties of propolis, especially in vitro and animal models (
Propolis, a resinous beehive product referred as " bee glue " , is collected from various plant sources, such as buds of conifer and poplar trees, by honeybees (Apis mellifera). Honeybees blend this resinous non-toxic substance with their salivary secretions and wax flakes secreted from special glands on their abdomens. Propolis has been used as a healing agent for thousands of years in folk medicine. There is substantial evidence indicating that propolis exhibits a broad spectrum of therapeutic (biological/pharmacological) properties such as antimicrobial, anti-oxidant, anti-inflammatory, immunomodulatory, antitumor, anticancer, antiulcer, hepatoprotective, and cardioprotective properties. Propolis contains more than 200-300 natural compounds. The biological/pharmacological activities of propolis depend on the presence of a large number of polyphenols, mainly flavonoids (flavonoid aglycones), aromatic acids, phenolic acid esters (caffeates and ferulates), triterpenes, diterpenic acids and lignanes. The chemical composition and beneficial properties of propolis vary depending on the plant source, geographic origin and collection time. Present overview is an attempt to discuss the molecular mechanism(s) underlying the diverse biological effects of propolis.