Association between Osteoporosis and Metabolic Syndrome in Postmenopausal Women (original) (raw)
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Is metabolic syndrome related to postmenopausal osteoporosis? A retrospective study
Archives of Clinical and Experimental Medicine, 2018
Aim: To evaluate the difference between postmenopausal women with and without osteoporosis in terms of metabolic syndrome.Methods: A total of 98 postmenopausal women younger than 65 years, were enrolled in the study. According to the bone mineral density examination; 49 participants who had T-score>−2.5 at the spine or/and femoral neck were included in the group without osteoporosis (Group 1), and 49 participants who had T-score≤−2.5 at the spine or/and femoral neck were included in the osteoporosis group (Group 2). Patient’s profile which included all demographic data, particularly anthropometric evaluation and medical history was obtained. Serum fasting glucose, lipid profiles and 25 OH vitamin D levels were also recorded. Results: Age (p=0.001), menopausal age (p=0.003), systolic blood pressure (p=0.004) and diastolic blood pressure (p=0.001) of Group 2 were significantly higher than Group 1. There were no significant difference in terms of body mass index, weight, lipid profi...
Association between bone mineral density and metabolic syndrome in pre- and postmenopausal women
Endocrine Journal, 2011
In the agIng population, osteoporosis is an important public health problem worldwide due to its high morbidity and mortality. Also, metabolic syndrome (MS) is another very common medical problem of epidemic importance, and the number of patients with MS is rapidly increasing in industrialized countries. There have been many studies about the relationship between MS and bone metabolism, but their results are inconsistent. A population-based US study has shown that bone mineral density (BMD) of the femoral neck
Metabolic Syndrome and Bone Mineral Density in Post Menopausal Women: Is There Any Link?
Journal of Rheumatology and Arthritic Diseases, 2016
Introduction: Metabolic Syndrome (MetS) may have a protective or a negative effect on bone. The predominance of different components in individual patients may contribute to inconsistent results regarding its relationship with bone mineral density. Thus we analyzed the link between MetS and each of its components, and Bone Mineral Density (BMD) in post menopausal women. Methods: We conducted a cross sectional study including post menopausal women with and without MetS according to the National Cholesterol Education Program Adult Treatment Panel III criteria. The two groups were compared for BMD after adjusting for covariates that affected BMD significantly. A stepwise multiple linear regression analysis was used to identify independent predictors of BMD. Results: We included 170 women, 81 with MetS and 89 without MetS. The prevalence of MetS was 48%. In women with MetS, the mean BMD was 0.915 ± 0.159 g/cm 2 in lumbar spine and 0.865 ± 0.143 g/cm 2 in total hip. No significant statistical difference was found in comparison with the MetS free group (0.928 ± 0.160 g/cm 2 ; p=0.61 in lumbar spine, and 0.845 ± 0.143 g/cm 2 ; p=0.29 in total hip). Multiple regression analyses showed that waist circumference was associated with bone loss in lumbar spine (p= 0,003), while triglycerides was non-associated with bone loss on total hip (p= 0.05). Conclusion: It seems that BMD is not associated to MetS in post menopausal women. Abdominal obesity might be associated with bone loss underlying the possible effect of inflammation in pathophysiology of osteoporosis and bone loss.
Osteoporosis, vertebral fractures and metabolic syndrome in postmenopausal women
BMC Endocrine Disorders, 2014
Background: The combined effect of the metabolic syndrome (MS) risk factors on bone health has led to controversial results and it is still not clear whether this effect is protective or detrimental. The study aimed to examine the association between MS and bone mineral density (BMD), osteoporosis, and vertebral fractures (VFs) among ambulatory older postmenopausal women. Methods: 270 post-menopausal women with a mean age of 61.0 years ± 7.8 (50 to 90) with no prior known diagnosis of osteoporosis were recruited. BMD and Lateral vertebral fracture assessment (VFA) images were obtained using a GE Healthcare Lunar Prodigy densitometer. VFs were defined using a combination of Genant semiquantitative approach and morphometry. Results: The MS as defined by the NCEP-ATP III was present in 62 women (23.0%). According to the WHO classification, 82 had osteoporosis at any site (30.4%). VFs were identified in 116 (43.0%): 80 (29.6%) had grade 1 and 36 (13.3%) had grade 2 or 3. Women with MS had a significantly higher BMD and lower prevalence of osteoporosis (17.7% vs. 34.1%) than those without MS. No significant statistical difference was noted in prevalence of VFs (14.5 vs. 13.0%). There were significantly less women with MS among the group of osteoporotic women (13% vs. 27%; p = 0.018). Conditional regression binary analysis assessing the presence of osteoporosis as the dependent variable showed that women with a MS had a significant 71% decrease in the odds of being osteoporotic by BMD compared with women who had not MS accounting for age, BMI, number of parities and years since menopause. Conclusion: Women with MS had higher BMD at the hip and spine, suggesting a protective effect of MS on bone. However, the prevalence of VFs was similar between women with or without MS.
Relation between bone density and certain parameters of lipid status in postmenopausal women
Central European Journal of Medicine, 2012
The aim of the paper was to examine the relation between bone density and certain parameters of lipid status in postmenopausal women. The research involved 300 women referred to densitometric examination as they belonged to the risk group of postmenopausal women. All the examinees had the following biochemical parameters determined: total cholesterol, triglycerides, HDL cholesterol, LDL cholesterol, glycemia, serum Ca and P. Univariate logistic regression analyses showed that each year of age, menopause duration, AH are significantly connected to risk increase for the appearance of osteopenia or osteoporosis. Increase in values of SBP, DBP, cholesterol, LDL and triglyceride are connected with significant risk increase for the appearance of osteopenia or osteoporosis. Patients with AH are connected to 11 times elevated risk for the appearance of osteopenia or osteoporosis, cigarette smoking increased the risk by seven times, physical inactivity even by 52 times, CVD in the family ana...
Correlation between total cardiovascular risk and bone density in postmenopausal women
Central European Journal of Medicine, 2011
The aim of the paper was to examine the correlation between the total risk of cardiovascular events, determined by the SCORE (Systematic Coronary Risk Evaluation) system, and bone density in postmenopausal women. Examinees and method: The research involved 300 postmenopausal women. On the basis of bone density measurements, the participants were divided into three groups: group I — 84 examinees had osteoporosis, group II — 115 examinees had osteopenia, and group III — 101 examinees had normal bone mineral density (BMD). Results: Participants with high SCORE risk were statistically significantly older compared to low-risk women (60±3 vs. 55±5; p<0.001). They had significantly lower BMD and T scores (−1.09±0.94 vs. −2.86±0.63; p<0.001). Elevation of the SCORE risk by 1% caused a BMD decrease of 0.033 g/cm2(0.029 to 0.036 gr/cm2). Multivariate logistic regression analysis showed that the following factors caused a significant increase in the risk of decreasing BMD: every year of ...
Assessment of Osteoporosis in Post Menopausal Women: A Clinical Study
Nepal Journal of Obstetrics and Gynaecology, 2012
Osteoporosis is a metabolic disorder of the bones that is characterized by decreased bone density which predisposes to increased fracture risk. The disease can exist undiagnosed for a long time as it produces no distinct symptoms and fracture increases with age and after menopause, that bone density measurements accurately predict the risk for fractures in the short-term, and that treating asymptomatic women with osteoporosis reduces their risk for fracture. The present cross sectional study was undertaken to assess osteoporosis in postmenopausal women by measuring bone mineral density (BMD).
European Journal of Inflammation, 2014
We aimed to analyze bone mineralization and the effect of different risk factors for osteoporosis in postmenopausal women. We studied 2,756 postmenopausal subjects out of~10,000 records from the ROIS registry in the frame of the PROF Project, a population study carried out in Salento (Taranto, Brindisi, Leece) from 2009 to 2012. All subjects were assessed by phalangeal Quantitative Ultrasound (QUS) to evaluate their bone mineralization (assessed by Amplitude Dependent Speed of Sound, AD-SoS) and the association between demineralization and the presence of other conditions or risk factors. Mean age was 64±9.5 years and mean BMI was 28.7±3.5 Kg/m'. Pearson correlation analyses revealed a negative association between bone mineralization (AD-SoS) and BMI (P<O.OOl). By using multivariate logistic regression analysis, we observed significant values of Odds Ratios of osteoporosis (adjusted for age, physical activity and the use of drugs known to increase the risk of fractures) in subjects with diabetes and obesity: 1.39 (CI: 1,05-1,83) and 1.46 (CI: 1.20-1.78), respectively. A statistically significant linear trend of higher Odds Ratios of osteoporosis was found for increasing values of BMI. The percent change in the odds of vertebral fractures per single SD decrease of AD-SoS was 47% (P<O.OOl). Diabetes and obesity in postmenopausal women are likely to represent independent risk factors for osteoporosis. Phalangeal QUS showed a good power of predictivity in identifying subjects with vertebral fractures. Osteoporosis and fragility fractures represent a growing health problem in developed countries in terms of social costs and increased risk of death, especially in the elderly (1). Fracture incidence
Correlation between Osteocalcin, Non-HDL Cholesterol and Metabolic Syndrome in Postmenopausal Women
Journal of pharmaceutical and biomedical sciences, 2016
Background Osteoporosis, cardiovascular diseases (CVD), and metabolic syndrome (MS) are associated with a higher mortality rate. Bone tissues, adipocytes, and the brain interact together to control body weight and regulate glucose metabolism through osteocalcin (OC), a hormone secreted by the osteoblasts. The aim of our study was to establish the correlation between serum osteocalcin levels, features of MS and cardiovascular risk assessed through non-HDL-cholesterol levels in a group of postmenopausal women. Methods Retrospective study conducted over a period of 3 years on a group of 150 postmenopausal women, divided into two lots according to the presence or absence of MS. The diagnosis of MS was made based on NCEP ATP - III criteria. Serum osteocalcin has been correlated with specific components of MS and other atherogenic markers. Results OC values were lower in patients with MS compared to those without MS. Significant negative correlations were recorded between OC and the fasti...
Revista Brasileira de Ginecologia e Obstetrícia / RBGO Gynecology and Obstetrics
Objective It was aimed to compare visceral adiposity index (VAI) levels in patients with normal bone mineral density (BMD), osteopenia, and osteoporosis. Methods One hundred twenty postmenopausal women (40 with normal BMD, 40 with osteopenia, and 40 with osteoporosis) between the ages of 50 to 70 years were included in the study. For females, the VAI was calculated using the formula (waist circumference [WC]/[36.58 + (1.89 x body mass index (BMI))]) x (1.52/High-density lipoprotein [HDL]-cholesterol [mmol/L]) x (triglyceride [TG]/0.81 [mmol/L]). Results The time of menopause from the beginning was similar in all groups. Waist circumference was found to be higher in those with normal BMD than in the osteopenic and osteoporotic groups (p = 0.018 and p < 0.001, respectively), and it was also higher in the osteopenic group than in the osteoporotic group (p = 0.003). Height and body weight, BMI, blood pressure, insulin, glucose, HDL-cholesterol, and homeostasis model assessment-insuli...