Exploring the folate pathway in Plasmodium falciparum
John Hyde
Acta Tropica, 2005
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Transcriptional analysis of genes encoding enzymes of the folate pathway in the human malaria parasite Plasmodium falciparum
Niroshini Nirmalan
Molecular Microbiology, 2002
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Investigation of the molecular response to folate metabolism inhibition
Linda Hughes
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A 19-Base Pair Deletion Polymorphism in Dihydrofolate Reductase Is Associated with Increased Unmetabolized Folic Acid in Plasma and Decreased Red Blood Cell Folate
aron troen, Paul Jacques
Journal of Nutrition, 2008
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The dihydrofolate reductase domain of Plasmodium falciparum thymidylate synthase-dihydrofolate reductase. Gene synthesis, expression, and anti-folate-resistant mutants
Yongyuth Yuthavong
The Journal of biological chemistry, 1993
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Folate Insufficiency Due to MTHFR Deficiency Is Bypassed by 5-Methyltetrahydrofolate
rdeci knof
Journal of Clinical Medicine
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The molecular basis of folate salvage in Plasmodium falciparum: Characterization of two folate transporters
Sanjeev Krishna
Journal of Biological …, 2011
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Anti-folate drug resistance in Africa: meta-analysis of reported dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) mutant genotype frequencies in African Plasmodium falciparum parasite populations
John Barnwell
Malaria Journal, 2010
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Molecular genetic analysis of the human dihydrofolate reductase gene: relation with plasma total homocysteine, serum and red blood cell folate levels
Martin Den Heijer
European Journal of Human Genetics, 2007
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Folate metabolism as a source of molecular targets for antimalarials
Yongyuth Yuthavong
Future Microbiology, 2006
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Effect of enzyme and ligand protonation on the binding of folates to recombinant human dihydrofolate reductase: implications for the evolution of eukaryotic enzyme efficiency
Jim Appleman
Biochemistry, 1992
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The structure and properties of methylenetetrahydrofolate reductase from Escherichia coli suggest how folate ameliorates human hyperhomocysteinemia
Brian Guenther
Nature structural biology, 1999
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Plasmodium falciparum: a paradigm for alternative folate biosynthesis in diverse microorganisms?
Valerie de Crecylagard
Trends in Parasitology, 2008
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[6S]-5-methyltetrahydrofolate increases plasma folate more effectively than folic acid in women with the homozygous or wild-type 677C→T polymorphism of methylenetetrahydrofolate reductase
Paul Finglas
British Journal of Pharmacology, 2009
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Mutations within folate metabolising genes of Plasmodium falciparum in Cameroon
veronique penlap
African Journal of Biotechnology, 2009
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Dihydrofolate Reductase Deficiency Due to a Homozygous DHFR Mutation Causes Megaloblastic Anemia and Cerebral Folate Deficiency Leading to Severe Neurologic Disease
Harald Bode
The American Journal of Human Genetics, 2011
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A New Type of High Affinity Folic Acid Transporter in the Protozoan Parasite Leishmania and Deletion of Its Gene in Methotrexate-resistant Cells
christoph kundig
Journal of Biological Chemistry, 2002
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Folate and cobalamin metabolism in Plasmodium falciparum
Yongyuth Yuthavong
Parasitology today (Personal ed.), 1990
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Dual-Target Inhibitors of the Folate Pathway Inhibit Intrinsically Trimethoprim-Resistant DfrB Dihydrofolate Reductases
Joelle Pelletier
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Methylenetetrahydrofolate reductase: a link between folate and riboflavin?
Rima Rozen
The American journal of clinical nutrition, 2002
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Investigation of inter-individual variability of the one-carbon folate pathway: a bioinformatic and genetic review
Munir Pirmohamed
The Pharmacogenomics Journal, 2009
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Computational analysis of binding between malarial dihydrofolate reductases and anti-folates
Napat Songtawee
Malaria Journal, 2010
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Common Polymorphisms That Affect Folate Transport or Metabolism Modify the Effect of the MTHFR 677C > T Polymorphism on Folate Status
Lidia Susana Martinez Rios
The Journal of nutrition, 2015
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Life without dihydrofolate reductase FolA
Hannu Myllykallio
Trends in Microbiology, 2003
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Structural Perturbations in the Ala → Val Polymorphism of Methylenetetrahydrofolate Reductase: How Binding of Folates May Protect against Inactivation † , ‡
Brian Guenther
Biochemistry, 2006
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Resistance to antifolates in Plasmodium falciparum monitored by sequence analysis of dihydropteroate synthetase and dihydrofolate reductase alleles in a large number of field samples of diverse origins
Marcel Tanner
Molecular and Biochemical Parasitology, 1997
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A Structurally Altered Human Reduced Folate Carrier with Increased Folic Acid Transport Mediates a Novel Mechanism of Antifolate Resistance
Herbert Pinedo
Journal of Biological Chemistry, 1998
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Conversion of 5-Formyltetrahydrofolic Acid to 5-Methyltetrahydrofolic Acid Is Unimpaired in Folate-Adequate Persons Homozygous for the C677T Mutation in the Methylenetetrahydrofolate Reductase Gene
Irwin Rosenberg
Journal of Nutrition, 2000
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Regulation of Folate-Dependent Enzymes
mher mimi
Annals of the New York Academy of Sciences, 1971
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Impact of Folate Deficiency on DNA Stability
George Grant
The Journal of Nutrition, 2002
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Possible selection of host folate pathway gene polymorphisms in patients with malaria from a malaria endemic region in North East India
Jagadish kumar mahanta
Transactions of The Royal Society of Tropical Medicine and Hygiene, 2016
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Distribution, functionality and gene regulation of folate receptor isoforms: implications in targeted therapy
Manohar Ratnam
Advanced Drug Delivery Reviews, 2004
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A Polymorphism (80G->A) in the Reduced Folate Carrier Gene and Its Associations with Folate Status and Homocysteinemia
Daniel Lambert
Molecular Genetics and Metabolism, 2000
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