Penicillium marneffei infection: An AIDS-defining illness (original) (raw)
Related papers
Penicillium marneffei infection in an AIDS patient--a first case report from Malaysia
The Medical journal of Malaysia, 1995
We report a 39-year-old male who presented with tuberculous meningitis and was found also to be HIV-infected. In the course of his illness, he developed multiple opportunistic infections such as herpes genitalis, oesophageal candidiasis, CMV retinitis and finally succumbed to Penicillium marneffei septicaemia.
Penicilliosis presenting as fungating skin lesion
Journal of Infection and Chemotherapy
A 35-year-old HIV seropositive male patient presented with fever, weight loss, papules, nodules and fungating masses all over the body. Histopathological and mycological study of the skin biopsy tissue confirmed the diagnosis of penicilliosis. Although penicilliosis is restricted to Southeast Asia, more cases are being recognized in nonendemic countries.
PENICILLIUM MARNEFFEI-AIDS DEFINING ILLNESS
Our Dermatology Online
Background: Penicillium marneffei infection is the emerging fungal infection in the present day global scenario of HIV pandemic. P. marneffei is a dimorphic fungi with mycelial growth at 37oC. Suspicion of P.marneffei infection arises when a immunocompromised individuals especially HIV positive persons present with Molluscum contagiosum like skin lesions. But pulmonary manifestations are not characteristic of P.marneffei infection unless we test the sputum for fungal growth in individuals with low CD4 counts ,we may miss P.marneffei respiratory infection. Material and methods: 100 sputum samples from HIV patients with cough were examined for fungal pathogens by inoculating the samples on SDA and incubated at 28oC. The samples with greenish yellow mycelial growth with diffusible red pigment were inoculated on blood agar and SDA and incubates at 37oC for conversion to yeast. Results: We isolated two cases of P.marneffei out of 100 samples. The CD4 counts of the cases were 33 and 84. Conclusions: Early diagnosis and treatment reduces the mortality P.marneffei HIV patients.
An abdominal mass owing to Penicillium marneffei in an HIV-infected 7-year-old boy: case report
Annals of Tropical Paediatrics, 2006
A 7-year-old boy, referred with lymphoma, presented with prolonged fever and intra-abdominal lymphadenopathy demonstrated on computed tomography (CT) of the abdomen. Blood culture isolated Penicillium marneffei. The patient was subsequently proven serologically to be positive for human immunodeficiency virus (HIV). Treatment with amphotericin B followed by itraconazole was successful. A high level of clinical suspicion and awareness is necessary for early diagnosis of penicilliosis, especially in an era of an increasing prevalence of HIV in this region.
Disseminated penicilliosis (non-Penicillium marneffei) in an immuno-competent individual in Malaysia
Proceedings of Singapore Healthcare, 2017
Penicilliosis infection caused by Penicillium marneffei is the third most common opportunistic infection in Human Immunodeficiency Virus patients in Southeast Asia; however, Penicillium infection caused by non-P. marneffei is uncommon. We present a case of an immunocompetent male with disseminated penicilliosis (non-P. marneffei) presenting with recurrent empyema. The case described illustrates the challenges in managing a complicated systemic infection and the outcomes of a delayed presentation, in a potentially treatable disease.
Disseminated Penicillium marneffei Infection Associated with Human Immunodeficiency Virus
JAIDS Journal of Acquired Immune Deficiency Syndromes, 1993
A 33-year-old Spanish man presented with fever, expectoration, weight loss and lung cavitary lesions. HIV-positive serology, the lack of clinical improvement under anti-tuberculosis treatment, and the teamwork carried by clinicians, microbiologists and pathologists led to the diagnosis of Penicillium marneffei infection. This case supports the importance of the correct evaluation of the epidemiological history of the patients.
Disseminated Penicillium marneffei infection in an HIV infected patient returning from Vietnam
Revista Clinica Espanola, 2013
Penicillium marneffei (PM) infection is prevalent in SouthEast Asia and Southern China and has been considered an acquired immunodeficiency syndrome (AIDS)-defining disease. This report focused on the verrucoid proliferative lesions of P. marneffei infection in a 34-year-old Chinese female AIDS patient from a non-endemic region. She recovered after receiving intravenous amphotericin B followed by oral itraconazole therapy. At the same time, highly active antiretroviral therapy (HAART) was also started. She responded very well to the treatment.
Journal of Clinical Microbiology, 1999
We describe four cases of disseminated infection caused by endemic Penicillium marneffei in human immunodeficiency virus (HIV)-infected patients from the Manipur state of India. The most common clinical features observed were fever, anorexia, weight loss, hepatosplenomegaly, and, more importantly, skin lesions resembling molluscum contagiosum. The diagnosis in each of the four cases was achieved by direct examination of smears, observance of intracellular yeast-like cells multiplying by fission in biopsied tissue from skin lesions, and isolation of the dimorphic P. marneffei in pure culture in each case. In one case, fluorescent antibody studies allowed specific diagnosis. This report documents a new area in which P. marneffei is endemic, located in eastern India, and describes the first occurrence in India of P. marneffei in HIV-infected patients as well as the extension of the areas of P. marneffei endemicity westward to the northeastern state of Manipur.