Reply to Petros et al.: Early steriod therapy for patients with H1N1 influenza A virus infection (original) (raw)

Intensive Care Medicine - INTENS CARE MED

AI-generated Abstract

This response addresses comments made by Petros et al. regarding the study on early corticosteroid therapy for severe H1N1 influenza A patients upon ICU admission. The authors emphasize that while corticosteroid use is not recommended per current guidelines, their analysis revealed no significant mortality difference between treated and untreated patients, although superinfections were notably higher in the treatment group. They rebutted Petros et al.'s assertions about confounding factors influencing outcomes, reinforcing that factors like severity of illness were adequately controlled in their multivariate analysis, ultimately concluding that corticosteroid therapy should be avoided in cases of primary influenza pneumonia.

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