Genetic polymorphism of cytochrome P4501A1, microsomal epoxide hydrolase, and glutathione S-transferases Ml and Tl in Zimbabweans and Venda of Southern Africa (original) (raw)

Pharmacogenetics, 1998

Abstract

The expression and regulation of the xenobiotic metabolizing enzymes, cytochrome P4501A1 (CYP1A1), microsomal epoxide hydrolase (mEH) and glutathione S-transferases (GSTM1 and GSTT1), and their metabolic balance in the cells of target organs may determine whether exposure to carcinogens results in cancer (Daly et al, 1994). The genes for these enzymes exist as various mutant variants resulting in metabolic polymorphisms where a proportion of the population exhibits deficient, reduced or enhanced activity of a ...

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