Investigation on the presence of polyomavirus, herpesvirus, and papillomavirus sequences in colorectal neoplasms and their association with cancer (original) (raw)

2009, International Journal of Cancer

AI-generated Abstract

This study investigates the prevalence of polyomavirus, herpesvirus, and papillomavirus sequences in colorectal neoplasms to assess their association with cancer. Using quantitative real-time PCR and sequencing on a cohort of colorectal adenocarcinomas, adenomas, and normal mucosa samples, the research primarily focused on detecting JCV, BKV, SV40, WUV, KIV, MCV, HCMV, EBV, and HPVs. Findings indicate that while most viral DNA was absent, HPV, particularly HPV-16, may play a role in a subset of colorectal cancers, suggesting potential implications for cancer prevention through HPV vaccination.