Inhibition of tyrosine hydroxylase expression in α-synuclein-transfected dopaminergic neuronal cells (original) (raw)

Inhibition of tyrosine hydroxylase expression in α-synuclein-transfected dopaminergic neuronal cells

Although the aberrant expression of α-synuclein (α-Syn) is toxic to dopaminergic neurons, little is known about the correlation between the abnormality of α-Syn and the expression of tyrosine hydroxylase (TH), a rate-limiting enzyme for the synthesis of dopamine neurotransmitter. In this study, the MES23.5 rat dopaminergic cell line transfected with wild-type human α-Syn cDNA (hα-Syn) construct was used to investigate