Pulmonary Vein Isolation to Reduce Future Risk of Atrial Fibrillation in Patients Undergoing Typical Flutter Ablation: Results from a Randomized Pilot Study (REDUCE AF) (original) (raw)

Journal of cardiovascular electrophysiology, 2015

Abstract

This study examined incidence of AF following cavotricuspid isthmus (CTI) ablation alone or CTI plus prophylactic pulmonary vein isolation (PVI) in patients presenting with isolated atrial flutter (AFL) with no history of AF. We enrolled 216 patients with isolated typical atrial flutter and randomized them to CTI alone (group 1, n = 108, 61.2±9.7 year, 75% male) or CTI+PVI ablation (group 2, n = 108, 62.4±9.3 year, 73% male). Insertible Loop Recorder (ILR) was implanted in 21 and 19 patients from group 1 and 2, respectively. Remaining patients were monitored with event recorders, ECG, 7-day Holter. Follow-up period was for 18±6 months. Compared to group 1, group 2 had significantly longer procedural duration (75.9±33 min vs. 161±48 min [p <0.001]) and fluoroscopy time (15.9±12.3 min vs 56.4+21 min [p<0.001]). At the end of follow-up, 65 (60.2%) in group 1 and 77 (71.3%) in group 2 were arrhythmia free off-AAD (log-rank p = 0.044). A subgroup analysis was performed with 55 year...

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