On the Genealogy of Tissue Engineering and Regenerative Medicine (original) (raw)

Tissue Engineering; Current Status & Futuristic Scope

Journal of Medicine and Life, 2019

Almost 30 years have passed since the term ‘tissue engineering’ was created to represent a new concept that focuses on the regeneration of neotissues from cells with the support of biomaterials and growth factors. This interdisciplinary engineering has attracted much attention as a new therapeutic means that may overcome the drawbacks involved in the current artificial organs and organ transplantation that have also been aiming at replacing lost or severely damaged tissues or organs. However, the tissues regenerated by tissue engineering and widely applied to patients are still minimal, including skin, bone, cartilage, capillary, and periodontal tissues. What are the reasons for such slow advances in clinical applications of tissue engineering? This article gives a brief overview of the current state of tissue engineering, covering the fundamentals and applications. The fundamentals of tissue engineering involve cell sources, scaffolds for cell expansion and differentiation, as well...

Tissue Engineering Concepts

Reference Module in Materials Science and Materials Engineering, 2016

One of the most significant breakthroughs in the field of mammalian regeneration has been the application of principles of bioengineering to guiding tissue regeneration. This approach is called tissue engineering. The goal of tissue engineering is the replacement of damaged tissues and organs with new tissue that mimics as closely as possible the overall structure and function of the original tissue. Some general strategies have been adopted to obtain new tissues they are: (1) use of autologous cells sources; (2) production of a scaffold for damaged target tissue; (3) tissue culture systems, and (4) Use of substances that induce the regeneration of damaged tissue. In this work, we discuss main aspects in the tissue engineering field.

2022 Klabukov's List of Top 100 Papers in Tissue Engineering and Regenerative Medicine (TERM

2022

#1. 3D bioprinting in tissue engineering and regenerative medicine. This review paper is primarily focused on bioprinting technology for biomedical applications. Bioprinting can be utilized for fabrication of wide range of tissue, based on which this chapter describes in detail its application in tissue regeneration. Further, the difficulties and potential in developing a construct for tissue regeneration are discussed herein. In this review paper, application of 3D bioprinting in tissue regeneration will be discussed in depth.

Challenges in tissue engineering

Journal of The Royal Society Interface - J R SOC INTERFACE, 2006

Almost 30 years have passed since a term 'tissue engineering' was created to represent a new concept that focuses on regeneration of neotissues from cells with the support of biomaterials and growth factors. This interdisciplinary engineering has attracted much attention as a new therapeutic means that may overcome the drawbacks involved in the current artificial organs and organ transplantation that have been also aiming at replacing lost or severely damaged tissues or organs. However, the tissues regenerated by this tissue engineering and widely applied to patients are still very limited, including skin, bone, cartilage, capillary and periodontal tissues. What are the reasons for such slow advances in clinical applications of tissue engineering? This article gives the brief overview on the current tissue engineering, covering the fundamentals and applications. The fundamentals of tissue engineering involve the cell sources, scaffolds for cell expansion and differentiation and carriers for growth factors. Animal and human trials are the major part of the applications. Based on these results, some critical problems to be resolved for the advances of tissue engineering are addressed from the engineering point of view, emphasizing the close collaboration between medical doctors and biomaterials scientists.

Advances in Regenerative Medicine and Tissue Engineering: Innovation and Transformation of Medicine

Stem cells international, 2018

Humans and animals lose tissues and organs due to congenital defects, trauma, and diseases. The human body has a low regenerative potential as opposed to the urodele amphibians commonly referred to as salamanders. Globally, millions of people would benefit immensely if tissues and organs can be replaced on demand. Traditionally, transplantation of intact tissues and organs has been the bedrock to replace damaged and diseased parts of the body. The sole reliance on transplantation has created a waiting list of people requiring donated tissues and organs, and generally, supply cannot meet the demand. The total cost to society in terms of caring for patients with failing organs and debilitating diseases is enormous. Scientists and clinicians, motivated by the need to develop safe and reliable sources of tissues and organs, have been improving therapies and technologies that can regenerate tissues and in some cases create new tissues altogether. Tissue engineering and/or regenerative me...