Assessment of Alterations in Antioxidant Enzymes and Histology of Liver and Cerebral Cortex of Developing Chick Embryo in Acrylamide Toxicity (original) (raw)

The acrylamide effect studied on antioxidants and histoarchitecture of 11th day old developing chick embryo liver and cerebral cortex that was exposed to 0.2 to 0.6mg concentrations at 72h incubation showed maximum superoxide dismutase and glutathione-S-transferase activities up to 0.4mg acrylamide treatment than control activity. These tissues catalase and glutathione peroxidase also showed a decrease in activity to minimum when embryo was administered with 0.6mg acrylamide than control. The decreased activities might be related to oxidative damage that occurs variably in these two tissues. The histological sections of tissues on microscopic analysis have showed mild degeneration, vacuole formation, necrosis and total damage in liver, and mild degeneration in cortex was found at 0.6mg acrylamide treatment. So our experimental results conclude that acryalmide was capable of producing major alterations in liver than in cerebral cortex of chick embryo at 72h incubation doses of 0.6mg acrylamide.