Two Dominant Dipolid Sequence Types of Candida tropicalis Isolates with Less Susceptibility to Flucoanzole in Taiwan from 1999 to 2006 (original) (raw)

Abstract

Background: Among the 162, 244, and 246 Candida tropicalis isolates collected in Taiwan Surveillance of Antimicrobial Resistance of Yeasts (TSARY) in 1999, 2002, and 2006, 23 (14.2%), 0, and 132 (53.7%) isolates with minimum inhibitory concentrations (MICs) of fluconazole ≥ 64 μg/ml, respectively. Methods: Multilocus sequence typing (MLST) was used to characterize the genetic profiles of 102 C. tropicalis isolates collected from 19 hospitals in Taiwan. Results: Among 61 differentiated DSTs, 11 had more than one isolates. Among 53 isolates with MICs ≥ 64 μg/ml, 36 (69.7%) belonged to these 11 types whereas, only 16 (32.7%) ones with MICs ≤ 16 μg/ml did (p=0.005). Furthermore, 24 (45.3%) with MICs ≥ 64 μg/ml belonged to two closely related DSTs (140 and 98) whereas, only 4 (8.2%) ones with MICs ≤ 16 μg/ml did (p=0.00008). Conclusions: Thus, two related DSTs of C. tropicalis isolates with less susceptibility to fluconazole were dominant in Taiwan from 1999 to 2006.

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