Structural implications of drug-resistant mutants of HIV-1 protease: High-resolution crystal structures of the mutant protease/substrate analogue complexes (original) (raw)

Kinetic, Stability, and Structural Changes in High-resolution Crystal Structures of HIV-1 Protease with Drug-resistant Mutations L24I, I50V, and G73S

Yuan-fang Wang, Irene Weber

Journal of Molecular Biology, 2005

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Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 A resolution crystal structures of HIV-1 protease mutants with substrate analogs

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FEBS Journal, 2005

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Inhibitor binding at the protein interface in crystals of a HIV1 protease complex

Renata Collard, Jiří Brynda

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Moses Prabu

2002

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Structure of a G48H mutant of HIV-1 protease explains how glycine-48 replacements produce mutants resistant to inhibitor drugs

Lin Hong

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Structure of a G48H mutant of HIV-1 protease explains how glycine-48 replacements produce mutants resistant to inhibitor drugs1

Stephen Foundling

FEBS letters, 1997

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The crystal structures at 2.2-A resolution of hydroxyethylene-based inhibitors bound to human immunodeficiency virus type 1 protease show that the inhibitors are present in two distinct orientations

Michael Minnich

Journal of Biological Chemistry, 1994

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Crystal structure of HIV-1 protease in situ product complex and observation of a low-barrier hydrogen bond between catalytic aspartates

Amit Das

Proceedings of the National Academy of Sciences, 2006

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Three-dimensional solution structure of the HIV-1 protease complexed with DMP323, a novel cyclic urea-type inhibitor, determined by nuclear magnetic resonance spectroscopy

Peter Domaille

Protein Science, 2008

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Atomic resolution crystal structures of HIV-1 protease and mutants V82A and I84V with saquinavir

Irene Weber, Yuan-fang Wang

Proteins: Structure, Function, and Bioinformatics, 2007

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Crystal Structure of Lysine Sulfonamide Inhibitor Reveals the Displacement of the Conserved Flap Water Molecule in Human Immunodeficiency Virus Type 1 Protease

Tim Jonckers

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Structural and kinetic analysis of drug resistant mutants of HIV-1 protease

Yuan-fang Wang, Irene Weber

European Journal of Biochemistry, 1999

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Caught in the Act: The 1.5 Å Resolution Crystal Structures of the HIV-1 Protease and the I54V Mutant Reveal a Tetrahedral Reaction Intermediate †

Irene Weber

Biochemistry, 2007

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Crystal structures of HIV protease V82A and L90M mutants reveal changes in the indinavir-binding site

Yuan-fang Wang, Irene Weber

European Journal of Biochemistry, 2004

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Analysis of the HIV-2 protease’s adaptation to various ligands: characterization of backbone asymmetry using a structural alphabet

Anne-claude Camproux

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Ultra-high Resolution Crystal Structure of HIV-1 Protease Mutant Reveals Two Binding Sites for Clinical Inhibitor TMC114

Robert Harrison

Journal of Molecular Biology, 2006

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Insights into the mechanism of drug resistance: X-ray structure analysis of G48V/C95F tethered HIV1 protease dimer/saquinavir complex

Subhash Bihani

Biochemical and Biophysical Research Communications, 2010

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Crystal structure of a complex of HIV-1 protease with a dihydroxyethylene-containing inhibitor: comparisons with molecular modeling

Stephen Foundling

Protein …, 1992

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Cyclic HIV protease inhibitors capable of displacing the active site structural water molecule

Bruce Aungst

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Conformational variation of an extreme drug resistant mutant of HIV protease

Robert Harrison

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Studies on flexibility and binding affinity of Asp25 of HIV-1 protease mutants

Krishnan Ramanathan

International Journal of Biological Macromolecules, 2008

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High Resolution Crystal Structures of HIV-1 Protease with a Potent Non-peptide Inhibitor (UIC-94017) Active Against Multi-drug-resistant Clinical Strains

Yuan-fang Wang, Irene Weber

Journal of Molecular Biology, 2004

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Crystal structure of human immunodeficiency virus (HIV) type 2 protease in complex with a reduced amide inhibitor and comparison with HIV-1 protease structures

Chris Tantillo

Proceedings of the National Academy of Sciences, 1993

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Mechanism of Substrate Recognition by Drug-Resistant Human Immunodeficiency Virus Type 1 Protease Variants Revealed by a Novel Structural Intermediate

Moses Prabu

Journal of Virology, 2006

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Rational Design, Synthesis, and Crystallographic Analysis of a Hydroxyethylene-Based HIV-1 Protease Inhibitor Containing a Heterocyclic P1'-P2' Amide Bond Isostere

Thomas Meek

Journal of Medicinal Chemistry, 1994

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Structure of HOE/BAY 793 Complexed to Human Immunodeficiency Virus (HIV-1) Protease in Two Different Crystal Forms Structure/Function Relationship and Influence of Crystal Packing

Juraj Sedláček, Jochen Knolle

European Journal of Biochemistry, 1997

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Defective Hydrophobic Sliding Mechanism and Active Site Expansion in HIV-1 Protease Drug Resistant Variant Gly48Thr/Leu89Met: Mechanisms for the Loss of Saquinavir Binding Potency

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