Serum Phosphorylated Neurofilament Heavy Chain Is a Marker of Axonal Loss in Experimental Optic Neuritis (original) (raw)

Objectives We evaluated whether the measurement of serum phosphorylated neurofilament heavy chain ( pNF-H) titre is likely to be a valid biomarker of axonal injury in multiple sclerosis (MS). Methods Serum pNF-H concentrations were measured by ELISA in cases with relapsing-remitting (RR)-MS (n=81), secondary progressive (SP) MS (n=13) and primary progressive (PP)-MS; n=6) MS; first demyelinating event (FDE; n=82); and unaffected controls (n=135). A subset of MS cases (n=45) were resampled on one or multiple occasions. The Multiple Sclerosis Severity Score (MSSS) and MRI measures were used to evaluate associations between serum pNF-H status, disease severity and cerebral lesion load and activity.