Administration of 8-Hydroxy-2-(Di-n-Propylamino)tetralin in Raphe Nuclei Dorsalis and Medianus Reduces Serotonin Synthesis in the Rat Brain: Differences in Potency and Regional Sensitivity (original) (raw)

1991, Journal of Neurochemistry

Following administration of 8-hydroxy-2-(di-n-propy1amino)tetralin (8-OH-DPAT; 0.04-5.0 pg/O.S p1) in the raphe nucleus dorsalis (DR) or medianus (MR), the synthesis of serotonin (5-HT), as assessed by the accumulation of 5-hydroxytryptophan (5-HTP) after decarboxylase inhibition, was measured in various regions of the rat CNS. At all doses, 8-OH-DPAT in the DR significantly reduced 5-HTP accumulation in the striatum, nucleus accumbens, cortex, and prefrontal cortex, whereas even the highest dose had no effect in the hippocampus, hypothalamus, and spinal cord. One microgram of 8-OH-DPAT in the MR significantly reduced 5-HTP accumulation in the nucleus accumbens and prefrontal cortex, and 5 fig had an effect in all the areas except the striatum and spinal cord. One and 5 pg of 8-OH-DPAT, 8-Hydroxy-2-(di-n-propylamino)tetralin @OH-DPAT), a selective serotoninlA (~-HTIA) receptor agonist , has been found to exert antidepressant, anxiolytic, anticataleptic, and hyperphagic effects in rats