‘Imported’ melioidosis in Germany: relapse after 10 years (original) (raw)
Related papers
2013
In 2008, melioidosis was diagnosed in an agricultural worker from Thailand in the southern Jordan Valley in Israel. He had newly diagnosed diabetes mellitus, fever, multiple abscesses, and osteomyelitis. Burkholderia pseudomallei was isolated from urine and blood. Four of 10 laboratory staff members exposed to the organism received chemoprophylaxis, 3 of whom had adverse events. Melioidosis, which is caused by Burkholderia pseudomallei, is endemic to some areas of Southeast Asia and northern Australia (1,2). Recent data indicate that it is now endemic to most of the Indian subcontinent, southern
A Case of Imported Melioidosis Presenting as Prostatitis
Infection, 2003
We report a case of melioidosis in a previously healthy Belgian man. He presented with septicemia and prostatic abscesses 1 week after a trip to Vietnam. Burkholderia pseudomallei was isolated from multiple hemocultures. He was treated successfully with intravenous ceftazidime and trimethoprim-sulfamethoxazole, followed by a per-oral maintenance therapy of amoxicillin-clavulanate with supplementary amoxicillin. There was no need for surgical drainage. This is the second reported case of melioidosis in Belgium.
Imported melioidosis in Japan: a review of cases
Infection and Drug Resistance, 2018
Fourteen cases of reported melioidosis in Japan were reviewed. The mean age was 52.4 years (33-69 years), and all patients were male. All of the presumed exposures originated in Southeast Asia. The most common underlying disease was diabetes mellitus, including those patients with impaired glucose tolerance (n=8). As for mode of onset, 13 patients had acute infections and one had chronic infection. Of these 14 patients, the most common infection site on admission was lung (n=8), followed by bone (n=5), skin (n=4), gastrointestinal abscess formation (n=3), urinary tract (n=3), aorta (n=2), mediastinal lymph node swelling (n=1), and central nervous system (n=1). Bacteremia was observed in nine patients, and Burkholderia pseudomallei isolates were mostly susceptible to ceftazidime and carbapenem. Overall mortality was 14.3%. Melioidosis is a rare infection in Japan, with all known cases to date having been imported from Southeast Asia. Diabetes was a common risk factor.
Sri Lankan Journal of Infectious Diseases, 2012
Melioidosis is an emerging infection in Sri Lanka. Since the clinical presentation of melioidosis is not distinctive, a high index of clinical suspicion is required. Definitive diagnosis is usually made by isolation of the causative bacterium, Burkholderia pseudomallei, in culture. Although it is not a difficult bacterium to culture, initial identification of the isolate requires prior experience with B. pseudomallei. A case report of a patient with acute onset of lung abscess with a positive sputum culture for B. pseudomallei is presented.
Case Review of Melioidosis in a Tertiary Care Centre from Northern Sri Lanka
International Journal of TROPICAL DISEASE & Health, 2019
Melioidosis is sporadically reported from various parts of Sri Lanka. It is a major recent endemic in Northern Sri Lanka. The causative organism Burkholderia pseudomallei, a Gram-negative, oxidase positive bacillus. The first case of melioidosis was reported in a European tea broker in 1927 in Sri Lanka. We present a case series of seven patients of culture or serologically proven melioidosis from Northern Sri Lanka, highlighting the different clinical manifestations of the disease .Melioidosis had an array of clinical presentation involving multiple abscesses in the skin, liver, spleen, mediastinum and septic arthritis. It presented as either an acute fulminant septicemia with a high mortality or a chronic localized infection. Most cases had predisposing risk factors such as diabetes, chronic kidney disease and occupational risk.
Melioidosis- Report of Two Cases
Journal of Clinical & Biomedical Research, 2020
Melioidosis which is caused by burkholderia pseudomallei occurs predominantly in Southeast Asia. Cases are now being reported from india as well. It can present with varying clinical manifestations like pneumonia, septicemia, arthritis, abscess etc. Neurologic meliodiosis, though rare can occur in upto 3-4% cases. Here we present two cases of melioidosis from Indian subcontinent, one involving central nervous system causing cerebral abscess and second one involving multiple splenic and liver abscess with bacteremia. First patient with cerebral abscess was managed with surgical debridement with antibiotics and discharged in a stable condition after 15 days while the bacteremic patient developed septic shock with mutiorgan failure and succumbed to death after 12 days of treatment
American Journal of Medical Case Reports, 2019
We describe the case of a 47 years old Sri Lankan man living in Oman with melioidosis and the resultant occupational risk of exposure to 5 laboratory staff members to the causative agent, Burkholderia pseudomallei. Widely reported as an endemic disease in tropical and subtropical areas, B. pseudomallei was imported to Oman by our patient who had risk factors of diabetes mellitus and alcoholic cirrhotic liver disease. Microbiological and biochemical tests identified the gram negative bacillus, B. pseudomallei, in the patient's blood sample. Five laboratory workers had occupational exposure to Burkholderia pseudomallei and received post-exposure prophylaxis. Our report highlights the importance of early suspicion of the infection and managing the patient with the correct international protocols for melioidosis especially for patients with severe sepsis and septic shock in the Intensive Care Unit (ICU). Furthermore, the importance of increased awareness among laboratory personnel and the need for good laboratory practices is reported. Furthermore, improved surveillance is essential to guide early diagnosis and prompt treatment.
Melioidosis: An emerging yet neglected bacterial zoonosis Volume 10 Issue 2 -2022
Melioidosis (Whitmore's disease) is an emerging disease caused by the Gram-negative saprophyte bacterium Burkholderia pseudomallei. It is a common but sometimes neglected zoonotic disease with a wide range of hosts, including humans. It has emerged as the leading cause of morbidity and mortality in tropical countries, such as Thailand, northern Australia, etc., and is continually emerging on a wider geographical scale. Recent epidemiological studies have suggested that most parts of Africa and the Middle East countries are environmentally suitable for B. Pseudomallei. Bacteria can easily travel from Asia to the Americas via Africa, as shown by phylogenetic analyzes of sporadic cases recently reported in America. Although melioidosis is included in the category 2 bioterrorism agents, there is ignorance in general people and even among clinicians regarding the infection. The disease requires long-term treatment regimens with no assurance of bacterial clearance. Several vaccine candidates are being tested, but none have reached clinical trials in humans. Diagnostic tests are still in the development stage and have compromised specificity and sensitivity in endemic areas. Understanding the adaptations of this organism to environmental factors and basic awareness is of the utmost importance today. Therefore, this review aims to provide an overview of melioidosis, including risk factors, epidemiology, clinical presentation, diagnosis, and preventive measures, as well as recommendations to increase awareness of the disease as a major public health problem.
Melioidosis: An emerging yet neglected bacterial zoonosis
Melioidosis (Whitmore's disease) is an emerging disease caused by the Gram-negative saprophyte bacterium Burkholderia pseudomallei. It is a common but sometimes neglected zoonotic disease with a wide range of hosts, including humans. It has emerged as the leading cause of morbidity and mortality in tropical countries, such as Thailand, northern Australia, etc., and is continually emerging on a wider geographical scale. Recent epidemiological studies have suggested that most parts of Africa and the Middle East countries are environmentally suitable for B. Pseudomallei. Bacteria can easily travel from Asia to the Americas via Africa, as shown by phylogenetic analyzes of sporadic cases recently reported in America. Although melioidosis is included in the category 2 bioterrorism agents, there is ignorance in general people and even among clinicians regarding the infection. The disease requires long-term treatment regimens with no assurance of bacterial clearance. Several vaccine candidates are being tested, but none have reached clinical trials in humans. Diagnostic tests are still in the development stage and have compromised specificity and sensitivity in endemic areas. Understanding the adaptations of this organism to environmental factors and basic awareness is of the utmost importance today. Therefore, this review aims to provide an overview of melioidosis, including risk factors, epidemiology, clinical presentation, diagnosis, and preventive measures, as well as recommendations to increase awareness of the disease as a major public health problem.