Osteosarcoma of the skull in a child: case report and review of the literature (original) (raw)
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BMC Cancer, 2011
Background: Osteosarcoma is the most common primary bone malignancy in childhood and adolescence. However, it is very rare in children under 5 years of age. Although studies in young children are limited in number, they all underline the high rate of amputation in this population, with conflicting results being recently reported regarding their prognosis. Methods: To enhance knowledge on the clinical characteristics and prognosis of osteosarcoma in young children, we reviewed the medical records and histology of all children diagnosed with osteosarcoma before the age of five years and treated in SFCE (Société Française des Cancers et leucémies de l'Enfant) centers between 1980 and 2007. Results: Fifteen patients from 7 centers were studied. Long bones were involved in 14 cases. Metastases were present at diagnosis in 40% of cases. The histologic type was osteoblastic in 74% of cases. Two patients had a relevant history. One child developed a second malignancy 13 years after osteosarcoma diagnosis. Thirteen children received preoperative chemotherapy including high-dose methotrexate, but only 36% had a good histologic response. Chemotherapy was well tolerated, apart from a case of severe late convulsive encephalopathy in a one-year-old infant. Limb salvage surgery was performed in six cases, with frequent mechanical and infectious complications and variable functional outcomes. Complete remission was obtained in 12 children, six of whom relapsed. With a median follow-up of 5 years, six patients were alive in remission, seven died of their disease (45%), in a broad range of 2 months to 8 years after diagnosis, two were lost to follow-up. Conclusions: Osteosarcoma seems to be more aggressive in children under five years of age, and surgical management remains a challange.
A Case Report of Osteosarcoma of the Skull
Open Journal of Modern Neurosurgery, 2014
Background: Osteosarcoma is the most common primary malignancy and aggressive neoplasm of bone composed of spindle cells producing osteoid. The incidence of primary osteogenic sarcomas of the skull is about 1% to 2% of all skull tumors. Methods: We present an extraordinary case of osteosarcoma arising in the postero-temporal region of the skull. The clinical features, diagnosis and management are discussed. Results: A 34-year-old woman was operated in our department for mass, fixed to bone in the left postero-temporal area. Histopathology confirmed the diagnosis of osteogenic sarcoma. Conclusion: We review the literature of reported cases of primary osteogenic sarcomas of the skull to discuss the common clinical presentation, evaluation methods, and recommended treatment plans.
Osteosarcoma in very young children
Cancer, 2010
for the COSS Study Group BACKGROUND: This study was conducted to investigate presentation, treatment, and outcome in very young children with osteosarcoma. METHODS: The authors retrospectively analyzed the data of 2706 consecutive COSS patients with newly diagnosed osteosarcoma and identified 28 (1.0%) patients aged younger than 5 years at diagnosis. Demographic, diagnostic, tumor, treatment-related variables, response, and survival data were analyzed. RESULTS: Of the 28 preschoolers, 27 presented with high-grade central osteosarcoma of an extremity, and 1 had a secondary osteosarcoma of the orbit. This analysis focused on the 27 patients with extremity tumors. The size of the primary was large (!one-third of the involved bone) in 20 of 27 patients. Primary metastases were detected in 4 of 27 children. All patients received multiagent chemotherapy, and 11 of 18 analyzed tumors responded well (>90% necrosis) to neoadjuvant chemotherapy. Limb-sparing surgery was performed in 9 cases, ablative procedures were performed in 15, and, in 3 cases, no local surgery was performed. With a median follow-up of 4 years (6.2 years for survivors), 13 patients were alive. Four patients never achieved a complete remission, and 11 developed recurrences; 14 of these 15 patients died. Five-year overall and event-free survival probabilities were 51% (standard error of the mean [SE], 10%) and 48% (SE, 10%). Better survival was correlated with good response to chemotherapy and later time period of diagnosis. CONCLUSIONS: Osteosarcoma is extremely rare in preschool children. These patients often have large tumors that may require mutilating resections. Prognosis is in the range of that reported for older patients.
Skull osteosarcoma: illustrated review
Acta Neurochirurgica, 2004
A case of conventional intramedullary osteosarcoma (epithelioid subtype) with 10 years of evolution and another of high grade surface osteosarcoma of the chondroblastic type, both in the skull, gave rise to several diagnostic and therapeutic difficulties. Key points concerning the definition, classification, imaging, clinical series data and treatment options available for skull osteosarcoma are highlighted.
Clinical Medicine Insights: Pediatrics, 2019
Purpose of the study: Primary osteosarcoma of the temporal bone is an exceedingly rare pathology in the paediatric population. As of now, only 3 cases have been reported in the English literature. We describe the additional case of a 16-year-old girl with an osteosarcoma of the mastoid bone. This study aims to report a rare paediatric case of low-grade surface osteosarcoma of the temporal bone. Materials and methods used: A literature review was performed to better understand paediatric osteosarcomas of the head and neck region, to optimize their investigation, to describe their histopathological and radiological characteristics, and to establish the optimal modalities of medical and surgical treatments. The research of previous published data was done using PubMed and Embase library with the keywords mentioned below. Results: The patient presented with a rapidly progressive left retroauricular lesion over a 3-week period. Radiological studies demonstrated aggressive and invasive fe...
Primary Osteosarcoma Arising From Skull- A Case Report
Journal of Medical Science And clinical Research, 2019
Primary osteosarcomas of skull which occur de novo are less frequent. Only 150 cases of osteosarcoma skull have been reported. [7] A 20 year old female presented with osteosarcoma in the Right temporal bone as painless temporal swelling, which rapidly enlarged since 1 month. She underwent Craniotomy and Biopsy elsewhere, Final Histopathology report was suggestive of Primary osteosarcoma.
Post-Paget Osteosarcomas of the Skull. Remarks on Five Cases
Tumori Journal, 1993
We report our experience with 5 cases of post-Paget osteosarcoma of the skull, a rare lesion of the neurocranium. Four patients were treated by surgery and radiotherapy and one by surgery alone. Two patients received chemotherapy. Hlstologically, the tumor was found to be an osteosarcoma, fibroblastic in 2 cases, mixed in 2, and osteoblastlc In 1. Combined treatment {surgery, radiotherapy and chemotherapy} positively influenced survival {median survival, 6 months). The
International Journal of Advanced Community Medicine , 2022
Osteosarcoma (OS) is a primary malignant bone tumor with a worldwide incidence. OS is a rare sarcoma that has the histological findings of osteoid production in association with malignant mesenchymal cells. Osteosarcoma is the eighth-most common form of childhood cancer. The most common site of origin is the metaphyseal region of tubular long bones, with 42% occurring in the femur, followed by the tibia, and the humerus. We reported a case of osteosarcoma of the right tibia in a 12-year-old patient.
Primary osteosarcoma of the skull
Australasian Radiology, 2006
Primary osteogenic sarcoma of the skull is an exceedingly rare condition. An adult male patient is described, who had a painless swelling in the right forehead that had rapidly enlarged in the previous 6 months. Radiological investigations showed a large destructive mass lesion involving the right side of the frontal bone with extension into the frontal sinus, causing marked extradural compression of brain parenchyma. Histopathological examination confirmed the lesion to be primary osteogenic sarcoma.
Primary bone osteosarcoma in the pediatric age: State of the art
Cancer Treatment Reviews, 2006
The current combination treatment, chemotherapy and surgery, has significantly improved the cure rate and the survival rate of primary bone osteosarcoma. The 5-year survival rate has increased in the last 30 years from 10% to 70%. Even in patients with poor prognosis, such as those with metastases at diagnosis, the 5-year survival rate has reached 20-30% due to chemotherapy and the surgical removal of metastases and primary tumor. However, the most effective drugs are still the same as those employed over the last 20 years as front line neoadjuvant or adjuvant chemotherapy: Doxorubicin, Cisplatin, Methotrexate, Ifosfamide. No standard, second line therapy exists for those who relapse. At relapse, due to the lack of new non-cross-resistant drugs, surgery is still the main option when feasible. Other drugs have been employed in relapsed patients with poor results. This article reviews the state of the art of treatment for bone osteosarcoma in the pediatric age.