Nitrogen dioxide and allergic sensitization in the 2005–2006 National Health and Nutrition Examination Survey (original) (raw)

2013, Respiratory Medicine

Respiratory Medicine (2013) 107, 1763e1772 air pollution estimates, we used the Community Multiscale Air Quality (CMAQ) model to increase the representation of rural participants in our sample. Logistic regression with population-based sampling weights was used to calculate adjusted prevalence odds ratios per 10 ppb increase in O 3 and NO 2 , per 10 mg/m 3 increase in PM 10 , and per 5 mg/m 3 increase in PM 2.5 adjusting for race, gender, age, socioeconomic status, smoking, and urban/rural status. Results: Using CMAQ data, increased levels of NO 2 were associated with positive IgE to any (OR 1.15, 95% CI 1.04, 1.27), inhalant (OR 1.17, 95% CI 1.02, 1.33), and indoor (OR 1.16, 95% CI 1.03, 1.31) allergens. Higher PM 2.5 levels were associated with positivity to indoor allergen-specific IgE (OR 1.24, 95% CI 1.13, 1.36). Effect estimates were similar using monitored data. Conclusions: Increased ambient NO 2 was consistently associated with increased prevalence of allergic sensitization. ª