Neuroepidemiology of epileptic seizures: A study from a tertiary care setting of Eastern India (original) (raw)
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Journal of Evolution of Medical and Dental Sciences, 2018
BACKROUND Epilepsy is one of the most common neurological disorders in the world. It is seen that relative frequency of various clinically important characteristics are different in persons with epilepsy (PWE) living in different geographical area. The purpose of this study is to determine the clinical and demographic profile of epilepsy in Bundelkhand region of central India. MATERIALS AND METHODS This is a descriptive study. All persons with epilepsy attending epilepsy clinic of neurology department were enrolled in this study. Detailed clinical history and general physical examination were carried out. CT scan head, EEG and other relevant investigations were done to determine cause and type of epilepsy. Antiepileptic drug therapy and compliance to treatment was also recorded. RESULTS One hundred and seventy six patients were included in this study. Mean age of onset were 17.4 + 10.4 years. Two-third of persons were from poor socioeconomic strata and from rural background. Age of onset of epilepsy was less than 15 years in 44% patients. Ten percent of patients gave family history of epilepsy among first degree relatives. Most common seizure type was generalised tonic-clonic seizures (68%). Sleep deprivation was the most common precipitating factor. Cause of seizure was idiopathic in 64% patients. Neurocysticercosis was found in 14% of patients and was the most common cause of secondary epilepsy. Eighty five percent were treated with single antiepileptic drug. Noncompliance for drug therapy was seen in 28% patients, which underscore the need for continuous and effective public awareness programme towards this condition. CONCLUSION Understanding of clinical and demographic profile of patients with epilepsy is needed to develop appropriate strategies for be tter and effective health planning.
Clinical Profile of Patients with Epilepsy
Journal of Nobel Medical College, 2015
Epilepsy is a common and diverse disorder with many different causes. Outcomes are varied with 60—70% of newly diagnosed people rapidly entering remission after starting treatment and 20—30% developing a drug-resistant epilepsy with consequent clinical and psychosocial distress. It is a Descriptive Cross-sectional study which was conducted in Tribhuvan University Teaching Hospital from January 2013 to January 2014.A total of 150 patients participated in the study. There was statistically significant association between numbers of seizures before starting medication and the frequency of seizure after starting medication (p<0.001).DOI: http://dx.doi.org/10.3126/jonmc.v3i1.12234Journal of Nobel Medical CollegeVol. 3, No.1 Issue 6, 2014, Page: 31-34
Profile of epilepsy in a tertiary care public sector hospital of western India
International Journal Of Community Medicine And Public Health
Background: Epilepsy is characterised by recurrent seizures due to a chronic underlying process. Its prevalence in India is 6.24/1000 population. The study aims to evaluate the commonest types of and clinical characteristics of epilepsy, and pharmacological management in these patients. Furthermore to assess, whether these variables are in agreement with other local and international studies?Methods: This cross-sectional observational study was carried out in an epilepsy clinic of a public sector hospital in India for a period of nine months. The study analysed medical records of patients during the study period. Simple descriptive statistical tests (Mean and Standard deviation) were used to describe the numerical values of the sample while qualitative data were presented by frequency distribution.Results: A total 297 patients were enrolled, after informed consent. The male: female ratio was 1.94. The age ranged between six months and 12 years (mean±SD =6.2±2.9). Majority of patient...
Background: Epilepsy is a common neurological disorder. It is estimated that there are at least 1.5 to 2 million epilepsy patients in Bangladesh3. Many of these patients are suffering from uncontrolled epilepsy which leads to cognitive deterioration, psychosocial dysfunction and increased morbidity and mortality. The causes behind uncontrolled epilepsy are multifactorial. Some are patient-related, some physician-related and some are medication-related. Objective: The purpose of the present study was to identify the factors responsible for uncontrolled epilepsy. Methodology: This case-control study was carried out in the epilepsy clinic of the Dhaka Medical College Hospital, Dhaka, Bangladesh from July 2010 to June 2012 (2 years). A total of 100 patients of which 50 consecutive patients of uncontrolled epilepsy (cases) and 50 age-matched controls with well controlled epilepsy (control) were recruited. Patients were interviewed according to a preformed questionnaire. Results: The mean ages of case and control groups were 21.84 ± 8.70 and 23.94 ± 10.28 years (p=0.273). The male female ratio was almost equal in both groups. The factors which turned out significant (p value <0.05) for uncontrolled epilepsy were lack of support from the family (p=0.032), lack of motivation about the disease (p=0.001), unavailability of drugs (p=0.001), irregular intake of anti-epileptic drugs (p=0.001), stopping AEDs willingly after transient control of seizures (p=0.001), lack of knowledge about the disease (p=0.003), treatment duration (p=0.005) & prognosis of the disease (p=0.026). Other factors were low annual income of the family (p=0.001), occupation (p=0.040), lower educational status (p=0.027) and residence in rural area (p=0.016). Important patient related factors were earlier age of onset of seizure (p=0.027), higher initial seizure frequency (p=0.012), associated clinical features (neurological deficits, mental retardation, behavioral abnormality) (p=0.030), abnormal brain imaging findings (p=0.013) and non response to first anti epileptic drug (p=0.005). Conclusion: Many of the factors behind uncontrolled epilepsy can be minimized by proper counseling of the patient at the start of treatment and regular follow up.
IOSR Journals , 2019
Background:Epilepsy could be a common nervous disorder. It's calculable that there square measure a minimum of 1.5 to 2 million brain disease patients in Bangladesh 3. Several of those patients square measure plagued by uncontrolled brain disease that results in psychological feature deterioration, psychosocial dysfunction and exaggerated morbidity and mortality. The causes behind uncontrolled brain disease square measure complex. Some square measure patient-related, some physician-related and a few square measure medication-related. Objective: the aim of the current study was to spot the factors liable for uncontrolled brain disease. Methodology: This case-control study was dispensed within the brain disease clinic of the Dhaka Shishu (Children) Hospital, Dhaka, Bangladesh from July 2016 to June 2018 (2 years). A total of 100 patients of which 50 consecutive patients of uncontrolled epilepsy (cases) and fifty age-matched controls with well controlled brain disease (control) were recruited. Patients were interviewed consistent with a preformed questionnaire. Results: The mean ages of case and control groups were 2.84 ± 4.70 and 3.94 ± 5.28 years (p=0.273). The male female magnitude relation was virtually equal in each teams. The factors which turned out significant (p value <0.05) for uncontrolled epilepsy were lack of support from the family (p=0.032), lack of motivation about the disease (p=0.001), unavailability of drugs (p=0.001), irregular intake of anti-epileptic drugs (p=0.001), stopping AEDs willingly after transient control of seizures (p=0.001), lack of knowledge about the disease (p=0.003), treatment duration (p=0.005) & prognosis of the disease (p=0.026). Other factors were low annual income of the family (p=0.001), occupation (p=0.040), lower educational status (p=0.027) and residence in rural area (p=0.016). Important patient related factors were earlier age of onset of seizure (p=0.027), higher initial seizure frequency (p=0.012), associated clinical features (neurological deficits, mental retardation, behavioral abnormality) (p=0.030), abnormal brain imaging findings (p=0.013) and non-response to first anti-epileptic drug (p=0.005). Conclusion: Many of the factors behind uncontrolled epilepsy can be minimized by proper counseling of the patient at the start of treatment and regular follow up.
Neuroepidemiology of Epilepsy in Northwest India
Annals Of neurosciences, 2010
went one interictal Electroencephalogram (EEG) and Computed Tomography (CT) scan after clinical evaluations and were diagnosed as idiopathic epilepsy (IE) or symptomatic epilepsy (SE) on the basis of these reports. The symptomatic epileptic patients with normal CT scan underwent Magnetic Resonance Imaging (MRI) scan for final diagnosis. Behavior disorders included running away from school, stealing money, sleep disturbances, temper tantrums, fighting and assaultative tendencies. The chronic cases were included as abnormals. Mental retardation was diagnosed clinically on the basis of having delay in development of speech or language as compared with other sibs in the family, poor interaction with others, associated delay in motor development, inadequate bowel and bladder control, abnormal facial features, salivary drooling and subnormal intellect. Informed consent was obtained as per institute ethical committee guidelines.
A longitudinal study of epilepsy in Kolkata, India
Epilepsia, 2010
Purpose: This study aimed to determine the prevalence, incidence, and mortality rates of epilepsy in the city of Kolkata, India. This is the first such longitudinal study in a heterogeneous urban Indian population. Methods: A two-stage door-to-door survey of a stratified random sample was undertaken within the municipal limits of Kolkata. Trained field workers detected and interviewed the cases using a simple screening questionnaire, and the detailed follow-up was done by neurologists. The survey was conducted annually for five consecutive years from March 2003 through February 2008. Results: A total of 52,377 (52.74% men) individuals were screened. There were 309 prevalent and 66 incident cases of active epilepsy. The prevalence and average annual incidence rate (AAIR) with 95% confidence interval (CI), age-standardized to World Standard Population, were 572.8 (509.79-641.54) per 100,000 and 27.27 (21.03-34.80) per 100,000 per year, respectively. The age-specific incidence rates of epilepsy showed bimodal distribution. During the 5-year period, 20 cases of active epilepsy died. The average annual mortality rate (AAMR) was 7.63 (95% CI 4.45-11.26) per 100,000 population per year. Compared to the general population of Kolkata, the all-cause standardized mortality ratio (SMR) for persons with epilepsy was 2.58 overall (men 3.67; women 1.77). There was no significant difference between slum and nonslum dwellers in epidemiologic parameters. Conclusions: The AAIR of epilepsy is comparable to that observed in developed countries, but AAMR is higher. The all-cause SMR for epilepsy relative to the general population is, however, similar to that of developed nations.
Pattern and outcome of epilepsy at department of neurology at cmc teaching hospital larkana
Pakistan Journal of Neurological Sciences, 2014
Epilepsy is third most common chronic neurological disease. Mortality is 2-3% more common in epilepsy patients than in general population. World wide survey have shown that epilepsy responds to treatment in about 70 % of epileptic patients and three fourth of the affected people do not get the treatment they need. So objective of our study was to know the outcome and pattern of epilepsy at Department of Neurology CMC teaching hospital Larkana ,so that in next step we could know which factors could reduce the morbitity and mortality due to epilepsy hence could prevent complications due to epilepsy. Total 404 patients were enrolled out of them 55 % were controlled and compared to world wide survey that in which 70 % of epileptic patients are controlled who get treatment so in comparison with world wide survey and this study there is gape of 15 % . therapy depends on type of seizure if there is no response then add on therapy is done,two third of the patients become seizure free after ...