Ca2+–Calmodulin regulates SNARE assembly and spontaneous neurotransmitter release via v-ATPase subunit V0a1. (original) (raw)

This paper investigates the role of calmodulin (CaM) in regulating SNARE assembly and neurotransmitter release, focusing on the V-ATPase subunit V0a1. It demonstrates that Ca2+–CaM interaction is critical for spontaneous vesicle release but does not affect acidification or stimulated vesicle cycling in certain Drosophila models. Through various experimental approaches, including electrophysiological analysis and imaging techniques, the study highlights the specific mechanisms by which CaM influences neurotransmission dynamics.