Interactions of phase equilibria, jet fluid dynamics and mass transfer during supercritical antisolvent micronization: The influence of solvents (original) (raw)

Interactions of phase equilibria, jet fluid dynamics, and mass transfer during supercritical antisolvent (SAS) micronization processes are explored, particularly highlighting the influence of various solvents. This study synthesizes prior research on how fluid dynamics, vapor-liquid equilibria, and mass transfer mechanisms interplay during SAS precipitation, fundamentally impacting particle morphology and process efficiency. Findings reveal that solvent choice critically impacts mixing behavior and resultant particle characteristics, informing the design of effective micronization processes.