Structural insights into the enzymes of the trypanothione pathway: targets for antileishmaniasis drugs (original) (raw)

The trypanothione pathway is integral to the survival of Leishmania parasites, which pose a significant health risk due to emerging drug resistance and associated side effects of current therapies. Detailed examination of the enzymes involved, specifically tryparedoxin and tryparedoxin-dependent peroxidase, reveals structural insights that can inform the development of novel antileishmaniasis drugs. Key interactions within the catalytic cycle and the enzymatic mechanisms underscore potential targets for therapeutic intervention to combat leishmaniasis more effectively.