Dendritic Cells Derived from Murine Colonic Mucosa Have Unique Functional and Phenotypic Characteristics (original) (raw)

Dendritic cells (DCs) from the murine colonic mucosa exhibit distinct functional and phenotypic characteristics compared to those from other tissues. The study isolates colonic DCs using a magnetic labeling technique, highlighting their unique ability to process antigens, lower expression of Toll-like receptors (TLRs), yet an enhanced responsiveness to certain stimuli. This suggests that colonic DCs are specialized to respond to their specific microenvironment, with implications for understanding mucosal immunity.