Human Bone Marrow Mesenchymal Stem Cell Behaviors on PCL/Gelatin Nanofibrous Scaffolds Modified with A Collagen IV-Derived RGD-Containing Peptide (original) (raw)

It is demonstrated that the peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptor proteins that function as transcription factors regulating the expression of genes. PPARs play essential roles in the regulation of cellular differentiation, development, and metabolism (carbohydrate, lipid, protein), and tumorigenesis of higher organisms. This study was conducted to reveal the effect of baicalin, a PPARγ activator, on erythroid differentiation of CD133+ cord blood hematopoietic stem cells. In order to investigate the effect of Peroxisome proliferator-activated receptor gamma PPARγ agonists including baicalin and troglitazone on erythropoeisis, CD133+ cells were isolated from human umbilical cord blood using MACS method and cultured in erythroid-inducing mediumadded with or without various dosages of two PPARγ activators (baicalin and troglitazone).Erythroid differentiation of CD133+ cord blood hematopoietic stem cells were assessed using microscopic morph...