IL-11/IL11RA receptor mediated signaling: a web accessible knowledgebase (original) (raw)

2013, Cell Communication and Adhesion

Interleukin-11 (IL-11) is a pleiotropic cytokine that belongs to gp130 family. It plays a signifi cant role in the synthesis and maturation of hematopoietic cells, inhibition of adipogenesis, regulation of embryo implantation, and trophoblasts invasion. Although IL-11 signaling has been described in several biological processes, a centralized resource documenting these molecular reactions induced by IL-11 is not publicly available. In the current study, we have manually annotated the molecular reactions and interactions induced by IL-11 from literature available. We have documented 40 unique molecules involved in 18 protein -protein interactions, 26 enzyme -substrate reactions, 7 translocation events, and 4 activation/ inhibition reactions. We have also annotated 23 genes reported to be differentially regulated under IL-11 stimulation. We have enabled the data availability in standard exchange formats from ' NetPath ' , a repository for signaling pathways. We believe that this will help in the identifi cation of potential therapeutic targets in IL-11-associated disorders.

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