Active Tuberculosis Is Associated with Worse Clinical Outcomes in HIV-Infected African Patients on Antiretroviral Therapy (original) (raw)

Abstract

Objective: This cohort study utilized data from a large HIV treatment program in western Kenya to describe the impact of active tuberculosis (TB) on clinical outcomes among African patients on antiretroviral therapy (ART).

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References (44)

  1. Non-TB group (overall) ,50 cells/ml 50-199 cells/ml $200 cells/ml 107 (101-113) 21 (18-23) 118 (112-123) 311 (264-362) 221 (197-245) 120 (96-146) 234 (205-266) 377 (291-475) 269 (246-293) 173 (145-203) 280 (251-310) 415 (336-502)
  2. Confidence intervals were derived based on the delta method of approximation, using estimates of the variance of the parameters produced by the GEE model. Note that the overall differences in CD4 counts present in the TB versus non-TB groups, are not evident among the three CD4 groupings suggesting that differences in CD4 response are a function of higher rates of baseline immunosuppression among TB patients rather than an independent TB-associated effect. doi:10.1371/journal.pone.0053022.t003
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