Direct Production of Reactive Oxygen Species from Aggregating Proteins and Peptides Implicated in the Pathogenesis of Neurodegenerative Diseases (original) (raw)

The direct production of reactive oxygen species from aggregating proteins plays a central role in the pathogenesis of several different neurodegenerative diseases

Omar El-agnaf

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Formation of hydrogen peroxide and hydroxyl radicals from Aβ and α-synuclein as a possible mechanism of cell death in Alzheimer’s disease and Parkinson’s disease1,2 1This article is part of a series of reviews on “Causes and Consequences of Oxidative Stress in Alzheimer’s Disease.” The full list ...

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Reactive Oxygen Species in Neurodegenerative Diseases: Implications in Pathogenesis and Treatment Strategies

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Protection from the Pathogenesis of Neurodegenerative Disorders, including Alzheimer's Disease, Amyotrophic Lateral Sclerosis, Huntington's Disease, and Parkinson's Diseases, through the Mitigation of Reactive Oxygen Species

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Apoptotic Neuronal Cell Death Induced by the Non-fibrillar Amyloid-beta Peptide Proceeds through an Early Reactive Oxygen Species-dependent Cytoskeleton Perturbation

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Promotion of transition metal-induced reactive oxygen species formation by β-amyloid

Stephen C Bondy

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Oxidative stress induces macroautophagy of amyloid β-protein and ensuing apoptosis

Alexei Terman

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Review on various factors responsible for neurodegenerative disorders

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Removing Protein Aggregates: The Role of Proteolysis in Neurodegeneration

Line Kimpe

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Pyruvate protection against β-amyloid-induced neuronal death: Role of mitochondrial redox state

Milagros Ramos

Journal of Neuroscience Research, 2003

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Amyloidogenic Proteins, in Their Fibrillar States, May Be Detrimental Via Different Mechanisms: Perspective of Po-Tential Curative/Preventive Strategies Against Neurodege-Nerative Disorders

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What is the role of protein aggregation in neurodegeneration?

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