Burian R.M. and Zallen, D.T., 2009, 'Genes'. In Bowler P.J. and Pickstone, J.V. (eds.), Cambridge History of the Life and Earth Sciences, Cambridge: Cambridge University Press, 432-450. (original) (raw)

A brief history of genetics: Chronology, concepts, and themes

2021

The history of genetics, since its origin, has transcended the scientific dimension, interweaving social, cultural, and political contexts. This brief contribution aims both to offer a chronological overview of scientific achievements in the field of genetics, starting from the pivotal work of Mendel and Darwin, and to outline concepts and themes that have emerged over time. It will show how the history of genetics allows us to reflect on some peculiar dynamics of the history of scientific thought, such as the evolution of scientists’ image, its relationship with society, the birth of new forms of cooperation (from the small lab to Big Science), and a constant, intense dialogue among the different social actors. All these elements still strongly characterize genetics today and investigating their historical roots will help us understand their nature and raison d'etre .

Genes, A Small History of a Big Concept

In this introductory chapter to my M.A. thesis, I trace the history of the gene and pre-gene concepts from Mendel through to the molecular revolution. I draw particular attention to two types of gene concept: the instrumental and material. I try to show how each iteration of the material gene developed from predictive and explanatory successes of the instrumental conception. I also highlight the role of emerging technologies in fueling this dialectic.

Gene Concepts and Genethics: Beyond Exceptionalism

Science and Engineering Ethics, 2008

The discursive explosion that was provoked by the new genetics could support the impression that the ethical and social problems posed by the new genetics are somehow exceptional in their very nature. According to this view we are faced with special ethical and social problems that create a challenge so fundamental that the special label of genethics is needless to justify. The historical account regarding the evolution of the gene concepts could serve us to highlight the limits of what we know about genes and what we can do with genes. The widespread notion about the exceptionality of genetic knowledge and its applicative possibilities is hardly justifiable and leads to misunderstandings regarding the conceptualization of the ethical and social problems we might face. Following a more realistic interpretation of the role of genes in human life we might avoid a whole set of fictive dilemmas and counterproductive regulatory efforts in bioethics. Bioethical discourse should move from the gene-centered scientific discourse toward the more sophisticated and complex discourses where human development represented as a matter of complex interactions between genomes and environments, between genes, educational factors, nutritional regimes, and other different developmental resources. If a gene is seen as one among the different developmental resources that are shaping a given human trait then both genethics and genetic exceptionalism could hardly be represented as a justified approach in discussing the ethical and social problems of genetics.

Switches and batteries: two models of gene regulation and a note on the historiography of science, p. 59

of heredity around genes following the rise of the discipline of genetics at the turn of the 20 th century. And, as the last century came to a close and the 21 st century began, we witnessed a new widening of approaches searching for the causes of heredity, characterized by a broader preoccupation for development, evolution, the environment, and even culture. As we will see, however, the metaphor of the hourglass is -like all metaphors -just as good as the questions and problems it has helped open.

The Manifestation of Modernity in Genetic Science

Genetics, the science of biological inheritance in living organisms, is the latest stage of an accelerating scientific evolution. It has moved from early attempts of tentatively understanding change and evolution to the most detailed descriptions and explanations of life. Moreover, contemporary manifestations of genetics are a matter of practical issues and implementations. Life is not a mere object of understanding and explanation, but emerges as endless options of interference. Life is a material, a resource – at disposal for life itself. Genetics is a manifestation of modernity. This is not so merely due to the trivial fact that variations of the science of genetics emerge and develop throughout the modern epoch, and that before modernity, there were neither such knowledge nor such practices. Rather, genetics is a manifestation of moder-nity as a cultural and mental disposition. Genetics and modernity correspond to each other; they are adequate to each other, and it may be suggested that genetics is conditioned by modernity, that it necessarily needs the institutions and dispositions of modernity – just as genetics expresses modernity and makes it evolve. Genetics is a typical and significant case of modernity and modernity's image of itself, of the world, and of that human being which is its historical inhabitant. In what follows, we will discuss genetic science as a manifestation of mod-ernity. Accordingly, we will, firstly, discuss the notion of modernity. Modernity will be understood and presented as an epoch and as a cultural and mental disposition. We will deploy a conceptual constellation which denotes specific and typical, constituting and regulating elements of modernity. Secondly, we will turn to the early developments of genetics as a science and as a practice with regard to key elements of modernity as a disposition, and with regard to their significance for images of what man would be, could be, should be. We will conclude the chapter with some reflections on the relationship between contemporary modern institutions and dispositions, and the swiftly emerging new insights and practices of genetics. Genetics represents an emergence through which moder-nity modernises itself. The general point of departure of the discussion refers to the classical as well as to the contemporary sociology of knowledge (Wissenssoziologie). According to Karl Mannheim and Ludwik Fleck, scientific knowledge is " situated "

Between the cross and the sword: the crisis of the gene concept

Genetics and Molecular Biology, 2007

Challenges to the gene concept have shown the difficulty of preserving the classical molecular concept, according to which a gene is a stretch of DNA encoding a functional product (polypeptide or RNA). The main difficulties are related to the overlaying of the Mendelian idea of the gene as a ‘unit’: the interpretation of genes as structural and/or functional units in the genome is challenged by evidences showing the complexity and diversity of genomic organization. This paper discusses the difficulties faced by the classical molecular concept and addresses alternatives to it. Among the alternatives, it considers distinctions between different gene concepts, such as that between the ‘molecular’ and the ‘evolutionary’ gene, or between ‘gene-P’ (the gene as determinant of phenotypic differences) and ‘gene-D’ (the gene as developmental resource). It also addresses the process molecular gene concept, according to which genes are understood as the whole molecular process underlying the capacity to express a particular product, rather than as entities in ‘bare’ DNA; a treatment of genes as sets of domains (exons, introns, promoters, enhancers, etc.) in DNA; and a systemic understanding of genes as combinations of nucleic acid sequences corresponding to a product specified or demarcated by the cellular system. In all these cases, possible contributions to the advancement of our understanding of the architecture and dynamics of the genetic material are emphasized.

Perspectives Anecdotal , Historical and Critical Commentaries on Genetics

2009

IN the early 1910s, researchers at the Marine Biological Laboratory (MBL) in Woods Hole, Massachusetts, might have wondered why a colleague, Thomas Hunt Morgan (Figure 1), began shipping fruit flies from his Columbia University lab to the MBL each summer. After all, the Woods Hole currents supplied the MBL with a rich variety of marine organisms and Morgan, an avid practitioner of experimental embryology, made good use of them. Yet those who knew Morgan well would not have been surprised by his insect stocks. A keen naturalist, Morgan studied a veritable menagerie of experimental animals—many of them collected in Woods Hole—as a student and later researcher at the MBL from 1890 to 1942. Moreover, Morgan always had a diversity of investigations going on simultaneously. ‘‘This was the way Morgan worked: he wasn’t happy unless he had a lot of different irons in the fire at the same time,’’ wrote A. H. Sturtevant, Morgan’s long-term collaborator (Sturtevant 2001, pp. 4–5). In Morgan’s f...